Experience-dependent modification of synaptic plasticity in visual cortex

Alfredo Kirkwood, M. G. Rioult, M. F. Bear

Research output: Contribution to journalArticle

Abstract

In many regions of the cerebral cortex, Ca2+ influx through NMDA (N-methyl-D-aspartate) sensitive glutamate receptors (NMDA receptors) can trigger two forms of synaptic plasticity: long-term depression (LTD) and long-term potentiation (LTP). LTD is induced by low levels of postsynaptic NMDA-receptor activation, for instance in response to low-frequency stimulation, whereas LTP is induced by the stronger activation that occurs following high-frequency stimulation. Theoretical studies have shown that the properties of synaptic LTD and LTP can account for many aspects of experience-dependent plasticity in the developing visual cortex, provided that the LTD-LTP crossover point (the modification threshold, θ(m)) varies as a function of the history of cortical activity. Here we provide direct experimental evidence that the value of θ(m) depends on sensory experience. We find in visual cortex of light-deprived rats that LTP is enhanced and LTD diminished over a range of stimulation frequencies, and that these effects can be reversed by as little as two days of light exposure. Our findings support the idea that a variable synaptic-modification threshold allows synaptic weights in neural networks to achieve a stable equilibrium.

Original languageEnglish (US)
Pages (from-to)526-528
Number of pages3
JournalNature
Volume381
Issue number6582
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Neuronal Plasticity
Long-Term Potentiation
Visual Cortex
Long-Term Synaptic Depression
Light
Glutamate Receptors
N-Methylaspartate
N-Methyl-D-Aspartate Receptors
Cerebral Cortex
Theoretical Models
History
Weights and Measures

ASJC Scopus subject areas

  • General

Cite this

Experience-dependent modification of synaptic plasticity in visual cortex. / Kirkwood, Alfredo; Rioult, M. G.; Bear, M. F.

In: Nature, Vol. 381, No. 6582, 1996, p. 526-528.

Research output: Contribution to journalArticle

Kirkwood, Alfredo ; Rioult, M. G. ; Bear, M. F. / Experience-dependent modification of synaptic plasticity in visual cortex. In: Nature. 1996 ; Vol. 381, No. 6582. pp. 526-528.
@article{19971a2bb6c94967a69a79a78769ae17,
title = "Experience-dependent modification of synaptic plasticity in visual cortex",
abstract = "In many regions of the cerebral cortex, Ca2+ influx through NMDA (N-methyl-D-aspartate) sensitive glutamate receptors (NMDA receptors) can trigger two forms of synaptic plasticity: long-term depression (LTD) and long-term potentiation (LTP). LTD is induced by low levels of postsynaptic NMDA-receptor activation, for instance in response to low-frequency stimulation, whereas LTP is induced by the stronger activation that occurs following high-frequency stimulation. Theoretical studies have shown that the properties of synaptic LTD and LTP can account for many aspects of experience-dependent plasticity in the developing visual cortex, provided that the LTD-LTP crossover point (the modification threshold, θ(m)) varies as a function of the history of cortical activity. Here we provide direct experimental evidence that the value of θ(m) depends on sensory experience. We find in visual cortex of light-deprived rats that LTP is enhanced and LTD diminished over a range of stimulation frequencies, and that these effects can be reversed by as little as two days of light exposure. Our findings support the idea that a variable synaptic-modification threshold allows synaptic weights in neural networks to achieve a stable equilibrium.",
author = "Alfredo Kirkwood and Rioult, {M. G.} and Bear, {M. F.}",
year = "1996",
doi = "10.1038/381526a0",
language = "English (US)",
volume = "381",
pages = "526--528",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6582",

}

TY - JOUR

T1 - Experience-dependent modification of synaptic plasticity in visual cortex

AU - Kirkwood, Alfredo

AU - Rioult, M. G.

AU - Bear, M. F.

PY - 1996

Y1 - 1996

N2 - In many regions of the cerebral cortex, Ca2+ influx through NMDA (N-methyl-D-aspartate) sensitive glutamate receptors (NMDA receptors) can trigger two forms of synaptic plasticity: long-term depression (LTD) and long-term potentiation (LTP). LTD is induced by low levels of postsynaptic NMDA-receptor activation, for instance in response to low-frequency stimulation, whereas LTP is induced by the stronger activation that occurs following high-frequency stimulation. Theoretical studies have shown that the properties of synaptic LTD and LTP can account for many aspects of experience-dependent plasticity in the developing visual cortex, provided that the LTD-LTP crossover point (the modification threshold, θ(m)) varies as a function of the history of cortical activity. Here we provide direct experimental evidence that the value of θ(m) depends on sensory experience. We find in visual cortex of light-deprived rats that LTP is enhanced and LTD diminished over a range of stimulation frequencies, and that these effects can be reversed by as little as two days of light exposure. Our findings support the idea that a variable synaptic-modification threshold allows synaptic weights in neural networks to achieve a stable equilibrium.

AB - In many regions of the cerebral cortex, Ca2+ influx through NMDA (N-methyl-D-aspartate) sensitive glutamate receptors (NMDA receptors) can trigger two forms of synaptic plasticity: long-term depression (LTD) and long-term potentiation (LTP). LTD is induced by low levels of postsynaptic NMDA-receptor activation, for instance in response to low-frequency stimulation, whereas LTP is induced by the stronger activation that occurs following high-frequency stimulation. Theoretical studies have shown that the properties of synaptic LTD and LTP can account for many aspects of experience-dependent plasticity in the developing visual cortex, provided that the LTD-LTP crossover point (the modification threshold, θ(m)) varies as a function of the history of cortical activity. Here we provide direct experimental evidence that the value of θ(m) depends on sensory experience. We find in visual cortex of light-deprived rats that LTP is enhanced and LTD diminished over a range of stimulation frequencies, and that these effects can be reversed by as little as two days of light exposure. Our findings support the idea that a variable synaptic-modification threshold allows synaptic weights in neural networks to achieve a stable equilibrium.

UR - http://www.scopus.com/inward/record.url?scp=0029941251&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029941251&partnerID=8YFLogxK

U2 - 10.1038/381526a0

DO - 10.1038/381526a0

M3 - Article

C2 - 8632826

AN - SCOPUS:0029941251

VL - 381

SP - 526

EP - 528

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6582

ER -