Expansion of FasL-expressing CD5+ B cells in type 1 diabetes patients

Ankit Saxena, Hideo Yagita, Thomas W. Donner, Abdel Rahim A. Hamad

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Fas ligand drives insulitis in the non-obese diabetic mouse model of type 1 diabetes (T1D) and negatively regulates IL-10-producing (IL-10pos) CD5+ B cells in pancreata. Relevance of these phenomena to the human disease is poorly understood. Here, using splenocytes from T1D, autoantibody (Ab+), and non-diabetic (ND) human subjects, we show that a subpopulation of CD5+ B cells that is characterized by expression of FasL (FasLhiCD5+) was significantly elevated in T1D subjects, many of whom had significantly reduced frequency of IL-10posCD5+ B cells compared to Ab+ subjects. The majority of FasLhiCD5+ B cells did not produce cytokines and were more highly resistant to activation-induced cell death than their IL-10posCD5+ counterparts. These results associate expansion of FasL-expressing CD5+ B cells with T1D and lay the groundwork for future mechanistic studies to understand specific role in disease pathogenesis.

Original languageEnglish (US)
Article number402
JournalFrontiers in immunology
Issue numberAPR
StatePublished - Apr 7 2017


  • Autoimmunity
  • B cell
  • CD5
  • Fas (CD95)
  • FasL (CD178)
  • Gld
  • IL-10
  • Type 1 diabetes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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