Abstract
We have expanded cerebrospinal fluid (CSF) T lymphocytes obtained from four patients with multiple sclerosis (MS). Fresh CSF cells were placed into culture with medium, interleukin-2, irradiated autologous peripheral blood mononuclear cells, and either myelin basic protein (BP) or measles virus antigen. Two CSF cell lines demonstrated a mild degree of antigen-specific proliferation to BP, a third reacted with measles virus, and the fourth demonstrated no known antigenic specificity. The percentage of HLA-DR + cells was increased in all four cell lines. The culture procedure has thus selected for a population of activated T cells, some of which demonstrate reactivity with antigens of potential relevance to the pathogenesis of MS.
Original language | English (US) |
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Pages (from-to) | 317-324 |
Number of pages | 8 |
Journal | Journal of Neuroimmunology |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - 1983 |
Externally published | Yes |
Keywords
- Antigenic specificity
- Cerebrospinal fluid
- Interleukin-2
- Measles virus
- Multiple sclerosis
- T. lymphocytes
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Clinical Neurology
- Neurology