TY - JOUR
T1 - Expanding the role of education in frontotemporal dementia
T2 - a functional dynamic connectivity (the chronnectome) study
AU - Premi, Enrico
AU - Cristillo, Viviana
AU - Gazzina, Stefano
AU - Benussi, Alberto
AU - Alberici, Antonella
AU - Cotelli, Maria Sofia
AU - Calhoun, Vince D.
AU - Iraji, Armin
AU - Magoni, Mauro
AU - Cotelli, Maria
AU - Micheli, Anna
AU - Gasparotti, Roberto
AU - Padovani, Alessandro
AU - Borroni, Barbara
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/9
Y1 - 2020/9
N2 - In the present study, we aim at investigating whether education modulates dynamical properties of time-varying whole-brain network connectivity (the chronnectome) in frontotemporal dementia (FTD) at a given level of symptom severity. Dynamic connectivity parameters were evaluated in 128 patients with FTD using independent component analysis, sliding-time window correlation, and k-means approach to resting state–magnetic resonance imaging data. We evaluated the relationship between education, a proxy measure of cognitive reserve, and 4 indexes of metastate dynamic connectivity: (1) the number of distinct metastates a patient passes through, (2) the number of switches from one metastate to another, (3) the span of the realized metastates, and (4) the total distance traveled in the state space. We found a significant inverse correlation between years of education and the 4 indexes of metastate dynamic fluidity (all p-values ≤ 0.03, false discovery rate–corrected). This study suggests that patients with FTD with higher education but comparable clinical severity show more global functional brain impairment, suggesting that patients with higher cognitive reserve can cope with more global brain fluidity reduction.
AB - In the present study, we aim at investigating whether education modulates dynamical properties of time-varying whole-brain network connectivity (the chronnectome) in frontotemporal dementia (FTD) at a given level of symptom severity. Dynamic connectivity parameters were evaluated in 128 patients with FTD using independent component analysis, sliding-time window correlation, and k-means approach to resting state–magnetic resonance imaging data. We evaluated the relationship between education, a proxy measure of cognitive reserve, and 4 indexes of metastate dynamic connectivity: (1) the number of distinct metastates a patient passes through, (2) the number of switches from one metastate to another, (3) the span of the realized metastates, and (4) the total distance traveled in the state space. We found a significant inverse correlation between years of education and the 4 indexes of metastate dynamic fluidity (all p-values ≤ 0.03, false discovery rate–corrected). This study suggests that patients with FTD with higher education but comparable clinical severity show more global functional brain impairment, suggesting that patients with higher cognitive reserve can cope with more global brain fluidity reduction.
KW - Chronnectome
KW - Cognitive reserve
KW - Education
KW - Frontotemporal
KW - MRI
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UR - http://www.scopus.com/inward/citedby.url?scp=85084808126&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2020.04.021
DO - 10.1016/j.neurobiolaging.2020.04.021
M3 - Article
C2 - 32447010
AN - SCOPUS:85084808126
VL - 93
SP - 35
EP - 43
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -