Expanding the living organ donor pool

positive crossmatch and ABO incompatible renal transplantation.

Mary Jo Holechek, Janet M. Hiller, Melinda Paredes, Jennifer C. Rickard, Robert A. Montgomery

Research output: Contribution to journalArticle

Abstract

There is a significant shortage of donor kidneys. As a result, kidney transplant candidates wait for prolonged periods of time for an organ, and over eight die every day while awaiting a kidney transplant. To improve this situation, the transplant community has actively sought creative solutions to the organ shortage. Many patients have willing live donors who are excluded from donation due to a positive crossmatch or blood group incompatibility. Plasmapheresis and intravenous immunoglobulin in combination can efficiently remove antibodies against donor tissue and blood group antigens and prevent these antibodies from returning after transplantation. Both strategies are complex but have good success rates and provide an opportunity for transplantation to those who might wait years for an organ or die waiting on the list Knowledge of these novel protocols is essential for the nephrology nurse who is often the first health care provider to discuss transplantation with end stage renal disease (ESRD) patients.

Original languageEnglish (US)
Pages (from-to)195-204
Number of pages10
JournalNephrology nursing journal : journal of the American Nephrology Nurses' Association
Volume30
Issue number2
StatePublished - 2003

Fingerprint

Living Donors
Kidney Transplantation
Transplantation
Tissue Donors
Transplants
Kidney
Blood Group Incompatibility
Waiting Lists
Nephrology
Plasmapheresis
Antibodies
Intravenous Immunoglobulins
Blood Group Antigens
Health Personnel
Chronic Kidney Failure
Nurses

Cite this

Expanding the living organ donor pool : positive crossmatch and ABO incompatible renal transplantation. / Holechek, Mary Jo; Hiller, Janet M.; Paredes, Melinda; Rickard, Jennifer C.; Montgomery, Robert A.

In: Nephrology nursing journal : journal of the American Nephrology Nurses' Association, Vol. 30, No. 2, 2003, p. 195-204.

Research output: Contribution to journalArticle

Holechek, Mary Jo ; Hiller, Janet M. ; Paredes, Melinda ; Rickard, Jennifer C. ; Montgomery, Robert A. / Expanding the living organ donor pool : positive crossmatch and ABO incompatible renal transplantation. In: Nephrology nursing journal : journal of the American Nephrology Nurses' Association. 2003 ; Vol. 30, No. 2. pp. 195-204.
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