Expanding the indications for radical trachelectomy a report on 29 patients with stage ib1 tumors measuring 2 to 4 centimeters

Stephanie L. Wethington, Yukio Sonoda, Kay J. Park, Kaled M. Alektiar, William P. Tew, Dennis S. Chi, Mario M. Leitao, Elizabeth L. Jewell, Richard R. Barakat, Nadeem R. Abu-Rustum

Research output: Contribution to journalArticle

Abstract

Objectives: Radical trachelectomy has enabled select women with stage I cervical cancer to maintain fertility after treatment. Tumor size greater than 2 cm has been considered a contraindication, and those patients denied trachelectomy. We report our trachelectomy experience with tumors measuring 2 to 4 cm. Methods: We retrospectively reviewed the medical records of all patients planned for fertility-sparing radical trachelectomy. Largest tumor dimension was determined by physical examination, preoperative magnetic resonance imaging, or pathologic evaluation. No patient received neoadjuvant chemotherapy. Results: Twenty-nine (26%) of 110 patients had stage IB1 disease with tumors 2 to 4 cm. Median age was 31 years (range, 22Y40 years), and 83% were nulliparous. Thirteen patients (45%) had squamous cell carcinoma, 12 patients (41%) had adenocarcinoma, and 4 patients (14%) had adenosquamous carcinoma. Thirteen (45%) of 29 patients had positive pelvic nodes. All para-aortic nodeswere negative.Owing to intraoperative frozen section, 13 patients (45%) underwent immediate hysterectomy and 1 patient (3%) definitive chemoradiation. Owing to high-risk features on final pathology, 6 patients (21%) who had retained their uterus received chemoradiation. Nine patients (31%) underwent a fertility-sparing procedure. At a median follow-up of 44 months (range, 1Y90 months), there was one recurrence. Conclusions: Expanding radical trachelectomy inclusion criteria towomen with 2- to 4-cm tumors allows for a fertility-sparing procedure in 30% of patients whowould otherwise have been denied the option, with no compromise in oncologic outcome.

Original languageEnglish (US)
Pages (from-to)1092-1098
Number of pages7
JournalInternational Journal of Gynecological Cancer
Volume23
Issue number6
DOIs
StatePublished - Jul 1 2013
Externally publishedYes

Keywords

  • Cervical cancer
  • Fertility preservation
  • Trachelectomy

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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    Wethington, S. L., Sonoda, Y., Park, K. J., Alektiar, K. M., Tew, W. P., Chi, D. S., Leitao, M. M., Jewell, E. L., Barakat, R. R., & Abu-Rustum, N. R. (2013). Expanding the indications for radical trachelectomy a report on 29 patients with stage ib1 tumors measuring 2 to 4 centimeters. International Journal of Gynecological Cancer, 23(6), 1092-1098. https://doi.org/10.1097/IGC.0b013e318296034e