Expanded pediatric cardiovascular simulator for research and training

George M. Pantalos, Constantine Ionan, Steven C. Koenig, Kevin J. Gillars, Tim Horrell, Sarina Sahetya, Jeff Colyer, Laman A. Gray

Research output: Contribution to journalArticle

Abstract

A mock circulation system has been developed to approximate key anatomic features and simulate the pressures and flows of an infant. Pulsatile flow is generated by 10 cc pulsatile ventricles (Utah infant ventricular assist device). Systemic vasculature is mimicked through the use of 3/8" ID bypass tubing with two flexible reservoirs to provide compliance. Vascular resistance, including pulmonary, aortic, and major branches, is controlled via a series of variable pinch clamps. The coronary branch has a dynamic resistor so that the majority of flow occurs during diastole. The system is instrumented to measure key pressures and flows. Right atrial pressure, left atrial pressure, pulmonary artery pressure, and mean aortic pressure are measured with high-fidelity pressure catheters (Millar Instruments, Houston, TX). Flows are measured by transit time ultrasonic flow probes (Transonic Systems, Ithaca, NY) in the pulmonary artery, aorta, coronary artery, and brachiocephalic artery along with assist device flow. The system can be tuned to create the hemodynamic values of a pediatric patient under normal or heart failure conditions. Once tuned to the desired hemodynamic conditions, the loop may be used to test the performance of various circulatory support systems including the intra-aortic balloon pump, left and right ventricular assist devices, or cardiopulmonary support systems such as extracorporeal membrane oxygenation.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalASAIO Journal
Volume56
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Pediatrics
Simulators
Pressure
Heart-Assist Devices
Atrial Pressure
Research
Pulmonary Artery
Hemodynamics
Pulsatile Flow
Extracorporeal Membrane Oxygenation
Diastole
Cardiovascular System
Ultrasonics
Vascular Resistance
Compliance
Aorta
Coronary Vessels
Arterial Pressure
Catheters
Heart Failure

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Pantalos, G. M., Ionan, C., Koenig, S. C., Gillars, K. J., Horrell, T., Sahetya, S., ... Gray, L. A. (2010). Expanded pediatric cardiovascular simulator for research and training. ASAIO Journal, 56(1), 67-72. https://doi.org/10.1097/MAT.0b013e3181c838ae

Expanded pediatric cardiovascular simulator for research and training. / Pantalos, George M.; Ionan, Constantine; Koenig, Steven C.; Gillars, Kevin J.; Horrell, Tim; Sahetya, Sarina; Colyer, Jeff; Gray, Laman A.

In: ASAIO Journal, Vol. 56, No. 1, 01.01.2010, p. 67-72.

Research output: Contribution to journalArticle

Pantalos, GM, Ionan, C, Koenig, SC, Gillars, KJ, Horrell, T, Sahetya, S, Colyer, J & Gray, LA 2010, 'Expanded pediatric cardiovascular simulator for research and training', ASAIO Journal, vol. 56, no. 1, pp. 67-72. https://doi.org/10.1097/MAT.0b013e3181c838ae
Pantalos, George M. ; Ionan, Constantine ; Koenig, Steven C. ; Gillars, Kevin J. ; Horrell, Tim ; Sahetya, Sarina ; Colyer, Jeff ; Gray, Laman A. / Expanded pediatric cardiovascular simulator for research and training. In: ASAIO Journal. 2010 ; Vol. 56, No. 1. pp. 67-72.
@article{9d072e5b8cf3437cb31ad41f35ef4c55,
title = "Expanded pediatric cardiovascular simulator for research and training",
abstract = "A mock circulation system has been developed to approximate key anatomic features and simulate the pressures and flows of an infant. Pulsatile flow is generated by 10 cc pulsatile ventricles (Utah infant ventricular assist device). Systemic vasculature is mimicked through the use of 3/8{"} ID bypass tubing with two flexible reservoirs to provide compliance. Vascular resistance, including pulmonary, aortic, and major branches, is controlled via a series of variable pinch clamps. The coronary branch has a dynamic resistor so that the majority of flow occurs during diastole. The system is instrumented to measure key pressures and flows. Right atrial pressure, left atrial pressure, pulmonary artery pressure, and mean aortic pressure are measured with high-fidelity pressure catheters (Millar Instruments, Houston, TX). Flows are measured by transit time ultrasonic flow probes (Transonic Systems, Ithaca, NY) in the pulmonary artery, aorta, coronary artery, and brachiocephalic artery along with assist device flow. The system can be tuned to create the hemodynamic values of a pediatric patient under normal or heart failure conditions. Once tuned to the desired hemodynamic conditions, the loop may be used to test the performance of various circulatory support systems including the intra-aortic balloon pump, left and right ventricular assist devices, or cardiopulmonary support systems such as extracorporeal membrane oxygenation.",
author = "Pantalos, {George M.} and Constantine Ionan and Koenig, {Steven C.} and Gillars, {Kevin J.} and Tim Horrell and Sarina Sahetya and Jeff Colyer and Gray, {Laman A.}",
year = "2010",
month = "1",
day = "1",
doi = "10.1097/MAT.0b013e3181c838ae",
language = "English (US)",
volume = "56",
pages = "67--72",
journal = "ASAIO Journal",
issn = "1058-2916",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Expanded pediatric cardiovascular simulator for research and training

AU - Pantalos, George M.

AU - Ionan, Constantine

AU - Koenig, Steven C.

AU - Gillars, Kevin J.

AU - Horrell, Tim

AU - Sahetya, Sarina

AU - Colyer, Jeff

AU - Gray, Laman A.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - A mock circulation system has been developed to approximate key anatomic features and simulate the pressures and flows of an infant. Pulsatile flow is generated by 10 cc pulsatile ventricles (Utah infant ventricular assist device). Systemic vasculature is mimicked through the use of 3/8" ID bypass tubing with two flexible reservoirs to provide compliance. Vascular resistance, including pulmonary, aortic, and major branches, is controlled via a series of variable pinch clamps. The coronary branch has a dynamic resistor so that the majority of flow occurs during diastole. The system is instrumented to measure key pressures and flows. Right atrial pressure, left atrial pressure, pulmonary artery pressure, and mean aortic pressure are measured with high-fidelity pressure catheters (Millar Instruments, Houston, TX). Flows are measured by transit time ultrasonic flow probes (Transonic Systems, Ithaca, NY) in the pulmonary artery, aorta, coronary artery, and brachiocephalic artery along with assist device flow. The system can be tuned to create the hemodynamic values of a pediatric patient under normal or heart failure conditions. Once tuned to the desired hemodynamic conditions, the loop may be used to test the performance of various circulatory support systems including the intra-aortic balloon pump, left and right ventricular assist devices, or cardiopulmonary support systems such as extracorporeal membrane oxygenation.

AB - A mock circulation system has been developed to approximate key anatomic features and simulate the pressures and flows of an infant. Pulsatile flow is generated by 10 cc pulsatile ventricles (Utah infant ventricular assist device). Systemic vasculature is mimicked through the use of 3/8" ID bypass tubing with two flexible reservoirs to provide compliance. Vascular resistance, including pulmonary, aortic, and major branches, is controlled via a series of variable pinch clamps. The coronary branch has a dynamic resistor so that the majority of flow occurs during diastole. The system is instrumented to measure key pressures and flows. Right atrial pressure, left atrial pressure, pulmonary artery pressure, and mean aortic pressure are measured with high-fidelity pressure catheters (Millar Instruments, Houston, TX). Flows are measured by transit time ultrasonic flow probes (Transonic Systems, Ithaca, NY) in the pulmonary artery, aorta, coronary artery, and brachiocephalic artery along with assist device flow. The system can be tuned to create the hemodynamic values of a pediatric patient under normal or heart failure conditions. Once tuned to the desired hemodynamic conditions, the loop may be used to test the performance of various circulatory support systems including the intra-aortic balloon pump, left and right ventricular assist devices, or cardiopulmonary support systems such as extracorporeal membrane oxygenation.

UR - http://www.scopus.com/inward/record.url?scp=76849110036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76849110036&partnerID=8YFLogxK

U2 - 10.1097/MAT.0b013e3181c838ae

DO - 10.1097/MAT.0b013e3181c838ae

M3 - Article

VL - 56

SP - 67

EP - 72

JO - ASAIO Journal

JF - ASAIO Journal

SN - 1058-2916

IS - 1

ER -