Exosomes: Fundamental Biology and Roles in Cardiovascular Physiology

Ahmed Ibrahim, Eduardo Marbán

Research output: Contribution to journalArticle

Abstract

Exosomes are nanosized membrane particles that are secreted by cells that transmit information from cell to cell. The information within exosomes prominently includes their protein and RNA payloads. Exosomal microRNAs in particular can potently and fundamentally alter the transcriptome of recipient cells. Here we summarize what is known about exosome biogenesis, content, and transmission, with a focus on cardiovascular physiology and pathophysiology. We also highlight some of the questions currently under active investigation regarding these extracellular membrane vesicles and their potential in diagnostic and therapeutic applications.

Original languageEnglish (US)
Pages (from-to)67-83
Number of pages17
JournalAnnual Review of Physiology
Volume78
DOIs
StatePublished - Feb 10 2016
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Extracellular vesicles
  • Intracellular communication
  • MicroRNA
  • Regenerative medicine
  • Stem cells

ASJC Scopus subject areas

  • Physiology

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