TY - JOUR
T1 - Exogenous estrogen in systemic lupus erythematosus
T2 - Oral contraceptives and hormone replacement therapy
AU - Petri, M.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - The role of exogenous estrogen in the initiation and maintenance of human SLE remains very controversial. Although cohort studies suggest an increase in the incidence of SLE with both oral contraceptives and hormone replacement therapy, recent retrospective studies suggest that the risk of flare is not increased with hormone replacement therapy. However, exogenous estrogen does increase hypercoagulability, an issue in SLE patients with antiphospholipid antibodies. The prospective SELENA study will ultimately address whether exogenous estrogen increases severe flares in SLE.
AB - The role of exogenous estrogen in the initiation and maintenance of human SLE remains very controversial. Although cohort studies suggest an increase in the incidence of SLE with both oral contraceptives and hormone replacement therapy, recent retrospective studies suggest that the risk of flare is not increased with hormone replacement therapy. However, exogenous estrogen does increase hypercoagulability, an issue in SLE patients with antiphospholipid antibodies. The prospective SELENA study will ultimately address whether exogenous estrogen increases severe flares in SLE.
KW - Hormone replacement therapy
KW - Oral contraceptives
KW - SLE
UR - http://www.scopus.com/inward/record.url?scp=0035048019&partnerID=8YFLogxK
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U2 - 10.1191/096120301676707393
DO - 10.1191/096120301676707393
M3 - Review article
C2 - 11315357
AN - SCOPUS:0035048019
SN - 0961-2033
VL - 10
SP - 222
EP - 226
JO - Lupus
JF - Lupus
IS - 3
ER -