Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor

Munekazu Yamakuchi, Marcella Ferlito, Craig N. Morrell, Kenji Matsushita, Craig A. Fletcher, Wangsen Cao, Charles J. Lowenstein

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Endothelial exocytosis of granules is a rapid response to vascular injury. However, the molecular machinery that regulates exocytosis in endothelial cells is not well understood. Recently developed techniques have defined the endothelial proteins that control vesicle and granule trafficking in endothelial cells. These techniques have revealed that syntaxin 4, synaptobrevin 3, and N-ethylmaleimide-sensitive factor (NSF) play a critical role in endothelial granule exocytosis. Additional studies have shown that nitric oxide regulates exocytosis by chemically modifying NSF. Further characterization of the factors that regulate exocytosis will lead to novel treatments for vascular diseases such as myocardial infarction and stroke.

Original languageEnglish (US)
Title of host publicationExocytosis and Endocytosis
PublisherHumana Press
Pages203-215
Number of pages13
ISBN (Print)9781588298652
DOIs
StatePublished - 2008

Publication series

NameMethods in Molecular Biology
Volume440
ISSN (Print)1064-3745

Keywords

  • Granule
  • N-ethylmaleimide-sensitive factor
  • Nitric oxide
  • P-selectin
  • Vesicle
  • Von Willebrand factor
  • Weibel-Palade body

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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