TY - JOUR
T1 - EXO1-A multi-tasking eukaryotic nuclease
AU - Tran, Phuoc T.
AU - Erdeniz, Naz
AU - Symington, Lorraine S.
AU - Liskay, R. Michael
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2004/12/2
Y1 - 2004/12/2
N2 - Exo1 was first isolated as a 5′ → 3′ exonuclease activity induced during meiosis in fission yeast and since that time has been implicated in a multitude of eukaryotic DNA metabolic pathways that include DNA repair, recombination, replication, and telomere integrity. Involvement in multiple pathways affecting genomic stability makes EXO1 a logical target for mutation during oncogenesis. Here, we review studies in several experimental systems that shed light on the role of Exo1 in these DNA transaction pathways, particularly those that may relate to oncogenesis.
AB - Exo1 was first isolated as a 5′ → 3′ exonuclease activity induced during meiosis in fission yeast and since that time has been implicated in a multitude of eukaryotic DNA metabolic pathways that include DNA repair, recombination, replication, and telomere integrity. Involvement in multiple pathways affecting genomic stability makes EXO1 a logical target for mutation during oncogenesis. Here, we review studies in several experimental systems that shed light on the role of Exo1 in these DNA transaction pathways, particularly those that may relate to oncogenesis.
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U2 - 10.1016/j.dnarep.2004.05.015
DO - 10.1016/j.dnarep.2004.05.015
M3 - Review article
C2 - 15474417
AN - SCOPUS:5044219898
SN - 1568-7864
VL - 3
SP - 1549
EP - 1559
JO - DNA Repair
JF - DNA Repair
IS - 12
ER -