Exercise performance in adolescents with autonomic dysfunction

Barbara E U Burkhardt, Phil R. Fischer, Chad K. Brands, Co Burn J Porter, Amy L. Weaver, Paul J. Yim, Paolo T. Pianosi

Research output: Contribution to journalArticle

Abstract

Objective: To test the hypothesis that excessive postural tachycardia is associated with deconditioning rather than merely being an independent sign of autonomic dysfunction in patients with postural orthostatic tachycardia syndrome (POTS). Study design: We retrospectively analyzed records from 202 adolescents who underwent both head up-tilt and maximal exercise testing. Patients were classified as POTS if they had ≥30 min-1 rise in heart rate (HR) after tilt-table test; and deconditioned if peak O2 uptake was 2 uptake among patients with POTS was similar to patients without POTS. HR was higher at rest and during exercise; whereas stroke volume was lower during exercise, and HR recovery was slower in patients with POTS compared with patients without POTS. Conclusions: Most patients who presented with chronic symptoms of dizziness, fatigue, or pre-syncope, were deconditioned, but, because the proportion of deconditioned patients was similar in POTS vs non-POTS groups, we conclude that HR changes in POTS are not solely because of inactivity resulting in deconditioning.

Original languageEnglish (US)
JournalJournal of Pediatrics
Volume158
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

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Postural Orthostatic Tachycardia Syndrome
Exercise
Heart Rate
Tachycardia
Tilt-Table Test
Syncope
Dizziness
Stroke Volume
Fatigue
Head

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Burkhardt, B. E. U., Fischer, P. R., Brands, C. K., Porter, C. B. J., Weaver, A. L., Yim, P. J., & Pianosi, P. T. (2011). Exercise performance in adolescents with autonomic dysfunction. Journal of Pediatrics, 158(1). https://doi.org/10.1016/j.jpeds.2010.07.020

Exercise performance in adolescents with autonomic dysfunction. / Burkhardt, Barbara E U; Fischer, Phil R.; Brands, Chad K.; Porter, Co Burn J; Weaver, Amy L.; Yim, Paul J.; Pianosi, Paolo T.

In: Journal of Pediatrics, Vol. 158, No. 1, 01.2011.

Research output: Contribution to journalArticle

Burkhardt, BEU, Fischer, PR, Brands, CK, Porter, CBJ, Weaver, AL, Yim, PJ & Pianosi, PT 2011, 'Exercise performance in adolescents with autonomic dysfunction', Journal of Pediatrics, vol. 158, no. 1. https://doi.org/10.1016/j.jpeds.2010.07.020
Burkhardt BEU, Fischer PR, Brands CK, Porter CBJ, Weaver AL, Yim PJ et al. Exercise performance in adolescents with autonomic dysfunction. Journal of Pediatrics. 2011 Jan;158(1). https://doi.org/10.1016/j.jpeds.2010.07.020
Burkhardt, Barbara E U ; Fischer, Phil R. ; Brands, Chad K. ; Porter, Co Burn J ; Weaver, Amy L. ; Yim, Paul J. ; Pianosi, Paolo T. / Exercise performance in adolescents with autonomic dysfunction. In: Journal of Pediatrics. 2011 ; Vol. 158, No. 1.
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