Exercise-Induced Hypertension, Endothelial Dysfunction, and Coronary Artery Disease in a Marathon Runner

Radha Goel, Farhan Majeed, Robert Vogel, Mary C. Corretti, Matthew Weir, Charles Mangano, Charles White, Gary D. Plotnick, Michael Miller

Research output: Contribution to journalArticle

Abstract

Aerobic activity performed on a regular basis is 1 of several lifestyle recommendations endorsed to reduce risk of coronary disease. However, 1 potential concern of arduous aerobic activity is exercise-induced hypertension. This is the first case to our knowledge, of accelerated coronary calcification in an otherwise asymptomatic middle-aged male marathon runner devoid of traditional cardiovascular risk factors. As a consequence of exercise-induced hypertension and associated oxidative stress, improvement of endothelial dysfunction occurred after antioxidant supplementation. In conclusion, vigorous aerobic activity in susceptible individuals may promote oxidative stress and coronary atherosclerosis.

Original languageEnglish (US)
Pages (from-to)743-744
Number of pages2
JournalAmerican Journal of Cardiology
Volume99
Issue number5
DOIs
StatePublished - Mar 1 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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