Exercise-induced expression of cardiac ATP-sensitive potassium channels promotes action potential shortening and energy conservation

Leonid V. Zingman, Zhiyong Zhu, Ana Sierra, Elizabeth Stepniak, Colin M L Burnett, Gennadiy Maksymov, Mark Anderson, William A. Coetzee, Denice M. Hodgson-Zingman

Research output: Contribution to journalArticle

Abstract

Physical activity is one of the most important determinants of cardiac function. The ability of the heart to increase delivery of oxygen and metabolic fuels relies on an array of adaptive responses necessary to match bodily demand while avoiding exhaustion of cardiac resources. The ATP-sensitive potassium (K ATP) channel has the unique ability to adjust cardiac membrane excitability in accordance with ATP and ADP levels, and up-regulation of its expression that occurs in response to exercise could represent a critical element of this adaption. However, the mechanism by which K ATP channel expression changes result in a beneficial effect on cardiac excitability and function remains to be established. Here, we demonstrate that an exercise-induced rise in K ATP channel expression enhanced the rate and magnitude of action potential shortening in response to heart rate acceleration. This adaptation in membrane excitability promoted significant reduction in cardiac energy consumption under escalating workloads. Genetic disruption of normal K ATP channel pore function abolished the exercise-related changes in action potential duration adjustment and caused increased cardiac energy consumption. Thus, an expression-driven enhancement in the K ATP channel-dependent membrane response to alterations in cardiac workload represents a previously unrecognized mechanism for adaptation to physical activity and a potential target for cardioprotection.

Original languageEnglish (US)
Pages (from-to)72-81
Number of pages10
JournalJournal of Molecular and Cellular Cardiology
Volume51
Issue number1
DOIs
StatePublished - Jul 2011
Externally publishedYes

Fingerprint

KATP Channels
Action Potentials
Adenosine Triphosphate
Workload
Membranes
Ion Channels
Adenosine Diphosphate
Up-Regulation
Heart Rate
Oxygen

Keywords

  • Exercise
  • Heart rate
  • K-ATP
  • KATP
  • Oxygen consumption
  • Remodeling

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

Exercise-induced expression of cardiac ATP-sensitive potassium channels promotes action potential shortening and energy conservation. / Zingman, Leonid V.; Zhu, Zhiyong; Sierra, Ana; Stepniak, Elizabeth; Burnett, Colin M L; Maksymov, Gennadiy; Anderson, Mark; Coetzee, William A.; Hodgson-Zingman, Denice M.

In: Journal of Molecular and Cellular Cardiology, Vol. 51, No. 1, 07.2011, p. 72-81.

Research output: Contribution to journalArticle

Zingman, Leonid V. ; Zhu, Zhiyong ; Sierra, Ana ; Stepniak, Elizabeth ; Burnett, Colin M L ; Maksymov, Gennadiy ; Anderson, Mark ; Coetzee, William A. ; Hodgson-Zingman, Denice M. / Exercise-induced expression of cardiac ATP-sensitive potassium channels promotes action potential shortening and energy conservation. In: Journal of Molecular and Cellular Cardiology. 2011 ; Vol. 51, No. 1. pp. 72-81.
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