Exercise-induced changes of cerebrospinal fluid vascular endothelial growth factor in adult chronic hydrocephalus patients

Jun Yang, Kaitlyn J. Shanahan, Leah P. Shriver, Mark Luciano

Research output: Contribution to journalArticle

Abstract

Vascular endothelial growth factor (VEGF) is a growth factor demonstrated to be a key factor in cerebral angiogenesis and neurogenesis. It has been considered a critical component in hippocampus neurogenesis and memory formation and has been observed to increase in the rat hippocampus after exercise. We previously found increased VEGF levels in experimental chronic hydrocephalus in several brain areas and cerebrospinal fluid (CSF), suggesting a role in the adaption to chronic hypoxia. Here we investigate the ability of moderate exercise to increase CSF-VEGF levels in adult chronic hydrocephalus patients. Lumbar CSF samples were collected from 17 normal pressure hydrocephalus patients. During CSF collection, 11 patients (exercise group) underwent a standard in-room occupational therapy session; six patients (no-exercise group) did not undergo a physical therapy session. CSF-VEGF levels were evaluated for increase related to exercise and the clinical response to CSF drainage. CSF-VEGF levels in the exercise group demonstrated significant increases 1-3 hours post-exercise compared with the levels 1-2 hours pre-exercise (p = 0.04), and also showed significantly higher levels than the no-exercise groups (p = 0.03). The post-exercise CSF-VEGF level in the group that did not clinically improve was significantly higher than both their own pre-exercise level (p = 0.02) and that seen in the clinically improving group (p = 0.05) after exercise. We conclude that CSF-VEGF levels can increase after moderate exercise even in elderly hydrocephalus patients. This suggests that a potential benefit of exercise, especially in CSF drainage non-improved patients, may exist via a central VEGF mechanism.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalJournal of Clinical Neuroscience
Volume24
DOIs
StatePublished - Feb 1 2016

Fingerprint

Hydrocephalus
Vascular Endothelial Growth Factor A
Cerebrospinal Fluid
Exercise
Neurogenesis
Hippocampus
Normal Pressure Hydrocephalus
Aptitude
Occupational Therapy
Intercellular Signaling Peptides and Proteins

Keywords

  • CSF
  • Exercise
  • Hydrocephalus
  • VEGF

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)

Cite this

Exercise-induced changes of cerebrospinal fluid vascular endothelial growth factor in adult chronic hydrocephalus patients. / Yang, Jun; Shanahan, Kaitlyn J.; Shriver, Leah P.; Luciano, Mark.

In: Journal of Clinical Neuroscience, Vol. 24, 01.02.2016, p. 52-56.

Research output: Contribution to journalArticle

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