Exercise heart rates in patients with hypertrophic cardiomyopathy

Hong Chang Luo; Veronica L. Dimaano; Jackelyn M. Kembro; Alex Hilser; David Hurtado-De-Mendoza; Iraklis Pozios; Miguel S. Tomas; Hulya Yalcin; Ketty Dolores-Cerna; Wilfredo Mormontoy; Miguel A. Aon; Duke Cameron; David A. Bluemke; Kerry J. Stewart; Stuart D. Russell; Jorge G. Cordova; Theodore P. Abraham; M. Roselle Abraham

doi:10.1016/j.amjcard.2015.01.548

Exercise heart rates in patients with hypertrophic cardiomyopathy

Hong Chang Luo, Veronica L. Dimaano, Jackelyn M. Kembro, Alex Hilser, David Hurtado-De-Mendoza, Iraklis Pozios, Miguel S. Tomas, Hulya Yalcin, Ketty Dolores-Cerna, Wilfredo Mormontoy, Miguel A. Aon, Duke Cameron, David A. Bluemke, Kerry J. Stewart, Stuart D. Russell, Jorge G. Cordova, Theodore P. Abraham, M. Roselle Abraham

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 patients with HC and 95 age-matched healthy controls. Patients with HC had higher prevalence of chronotropic incompetence and lower HRR_1-5min compared with controls. Exercise capacity, diastolic function (assessed by E/e') and left atrial volume index were associated with HRR_1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence but did not affect HRR_1min. In conclusion, impaired CR and HRR_1min are associated with advanced disease and do not appear to be independent clinical markers indicating high-risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy, and atrial pacing may be useful to increase exercise capacity in patients with HC.

Original language	English (US)
Pages (from-to)	1144-1150
Number of pages	7
Journal	American Journal of Cardiology
Volume	115
Issue number	8
DOIs	https://doi.org/10.1016/j.amjcard.2015.01.548
State	Published - 2015

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Luo, H. C., Dimaano, V. L., Kembro, J. M., Hilser, A., Hurtado-De-Mendoza, D., Pozios, I., Tomas, M. S., Yalcin, H., Dolores-Cerna, K., Mormontoy, W., Aon, M. A., Cameron, D., Bluemke, D. A., Stewart, K. J., Russell, S. D., Cordova, J. G., Abraham, T. P., & Abraham, M. R. (2015). Exercise heart rates in patients with hypertrophic cardiomyopathy. American Journal of Cardiology, 115(8), 1144-1150. https://doi.org/10.1016/j.amjcard.2015.01.548

Luo, HC, Dimaano, VL, Kembro, JM, Hilser, A, Hurtado-De-Mendoza, D, Pozios, I, Tomas, MS, Yalcin, H, Dolores-Cerna, K, Mormontoy, W, Aon, MA, Cameron, D, Bluemke, DA, Stewart, KJ, Russell, SD, Cordova, JG, Abraham, TP & Abraham, MR 2015, 'Exercise heart rates in patients with hypertrophic cardiomyopathy', American Journal of Cardiology, vol. 115, no. 8, pp. 1144-1150. https://doi.org/10.1016/j.amjcard.2015.01.548

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title = "Exercise heart rates in patients with hypertrophic cardiomyopathy",

abstract = "The exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 patients with HC and 95 age-matched healthy controls. Patients with HC had higher prevalence of chronotropic incompetence and lower HRR1-5min compared with controls. Exercise capacity, diastolic function (assessed by E/e') and left atrial volume index were associated with HRR1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence but did not affect HRR1min. In conclusion, impaired CR and HRR1min are associated with advanced disease and do not appear to be independent clinical markers indicating high-risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy, and atrial pacing may be useful to increase exercise capacity in patients with HC.",

author = "Luo, {Hong Chang} and Dimaano, {Veronica L.} and Kembro, {Jackelyn M.} and Alex Hilser and David Hurtado-De-Mendoza and Iraklis Pozios and Tomas, {Miguel S.} and Hulya Yalcin and Ketty Dolores-Cerna and Wilfredo Mormontoy and Aon, {Miguel A.} and Duke Cameron and Bluemke, {David A.} and Stewart, {Kerry J.} and Russell, {Stuart D.} and Cordova, {Jorge G.} and Abraham, {Theodore P.} and Abraham, {M. Roselle}",

year = "2015",

doi = "10.1016/j.amjcard.2015.01.548",

language = "English (US)",

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T1 - Exercise heart rates in patients with hypertrophic cardiomyopathy

AU - Luo, Hong Chang

AU - Dimaano, Veronica L.

AU - Kembro, Jackelyn M.

AU - Hilser, Alex

AU - Hurtado-De-Mendoza, David

AU - Pozios, Iraklis

AU - Tomas, Miguel S.

AU - Yalcin, Hulya

AU - Dolores-Cerna, Ketty

AU - Mormontoy, Wilfredo

AU - Aon, Miguel A.

AU - Cameron, Duke

AU - Bluemke, David A.

AU - Stewart, Kerry J.

AU - Russell, Stuart D.

AU - Cordova, Jorge G.

AU - Abraham, Theodore P.

AU - Abraham, M. Roselle

PY - 2015

Y1 - 2015

N2 - The exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 patients with HC and 95 age-matched healthy controls. Patients with HC had higher prevalence of chronotropic incompetence and lower HRR1-5min compared with controls. Exercise capacity, diastolic function (assessed by E/e') and left atrial volume index were associated with HRR1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence but did not affect HRR1min. In conclusion, impaired CR and HRR1min are associated with advanced disease and do not appear to be independent clinical markers indicating high-risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy, and atrial pacing may be useful to increase exercise capacity in patients with HC.

AB - The exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 patients with HC and 95 age-matched healthy controls. Patients with HC had higher prevalence of chronotropic incompetence and lower HRR1-5min compared with controls. Exercise capacity, diastolic function (assessed by E/e') and left atrial volume index were associated with HRR1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence but did not affect HRR1min. In conclusion, impaired CR and HRR1min are associated with advanced disease and do not appear to be independent clinical markers indicating high-risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy, and atrial pacing may be useful to increase exercise capacity in patients with HC.

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Exercise heart rates in patients with hypertrophic cardiomyopathy

Abstract

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