Exercise echocardiography in asymptomatic HCM: Exercise capacity, and not LV outflow tract gradient predicts long-term outcomes

Milind Y. Desai, Aditya Bhonsale, Parag Patel, Peyman Naji, Nicholas G. Smedira, Maran Thamilarasan, Bruce W. Lytle, Harry M. Lever

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives This study sought to assess long-term outcomes in asymptomatic or minimally symptomatic patients with hypertrophic cardiomyopathy (HCM) who underwent exercise echocardiography, without invasive therapies for relief of left ventricular outflow tract (LVOT) obstruction. Background Many HCM patients present with LVOT obstruction, mitral regurgitation (MR), and diastolic dysfunction, often requiring invasive therapies for symptomatic relief. However, a significant proportion of truly asymptomatic patients can be closely monitored. In HCM patients, exercise echocardiography has been shown to be a useful assessment of functional capacity and risk stratification. Methods We included 426 HCM patients (44 ± 14 years; 78% men) undergoing exercise echocardiography, excluding hypertensive heart disease of elderly, ejection fraction 100% of age-sex predicted METs had 1% event rate versus 12% in those achieving 100% of predicted METs.

Original languageEnglish (US)
Pages (from-to)26-36
Number of pages11
JournalJACC: Cardiovascular Imaging
Volume7
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • exercise echocardiography
  • hypertrophic cardiomyopathy
  • outcomes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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