Abstract
Introduction: Data on the association between exercise capacity and risk for heart failure (HF) in older adults are limited. Methods: This study examined the association of exercise capacity, and its change over time, with 10-year mortality and incident HF in 2,935 participants of the Health, Aging, and Body Composition Study without HF at baseline (age, 73.6 [SD=2.9] years; 52.1% women; 41.4% black; 58.6% white). This cohort was initiated in 1997-1998 and exercise capacity was evaluated with a long-distance corridor walk test (LDCW) at baseline and Year 4. Outcomes were collected in 2007-2008 and initial analysis performed in 2014. Results: Ten-year incident HF for completers (n=2,245); non-completers (n=331); and those excluded from LDCW for safety reasons (n=359) was 11.4%, 19.2%, and 23.0%, respectively. The corresponding 10-year mortality was 27.9%, 41.1%, and 42.4%. In models accounting for competing mortality, the adjusted subhazard ratio for HF was 1.37 (95% CI=1.00, 1.88;. p=0.049) in non-completers and 1.41 (95% CI=1.06, 1.89;. p=0.020) in those excluded versus completers. Non-completers (adjusted hazard ratio, 1.49; 95% CI=1.21, 1.84;. p<0.001) and those excluded (hazard ratio, 1.27; 95% CI=1.04, 1.55;. p=0.016) had elevated mortality. In adjusted models, LDCW performance variables were associated mainly with mortality. Only 20-meter walking speed and resting heart rate retained prognostic value for HF. Longitudinal changes in LDCW did not predict subsequent incident HF or mortality. Conclusions: Completing an LDCW is strongly associated with lower 10-year mortality and HF risk in older adults. Therefore, walking capacity may serve as an early risk marker.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Preventive Medicine |
| DOIs | |
| State | Accepted/In press - 2016 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Epidemiology
- Public Health, Environmental and Occupational Health
Cite this
Exercise Capacity, Heart Failure Risk, and Mortality in Older Adults : The Health ABC Study. / Georgiopoulou, Vasiliki V.; Kalogeropoulos, Andreas P.; Chowdhury, Ritam; Binongo, José Nilo G; Bibbins-Domingo, Kirsten; Rodondi, Nicolas; Simonsick, Eleanor Marie; Harris, Tamara; Newman, Anne B.; Kritchevsky, Stephen B.; Butler, Javed.
In: American Journal of Preventive Medicine, 2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Exercise Capacity, Heart Failure Risk, and Mortality in Older Adults
T2 - The Health ABC Study
AU - Georgiopoulou, Vasiliki V.
AU - Kalogeropoulos, Andreas P.
AU - Chowdhury, Ritam
AU - Binongo, José Nilo G
AU - Bibbins-Domingo, Kirsten
AU - Rodondi, Nicolas
AU - Simonsick, Eleanor Marie
AU - Harris, Tamara
AU - Newman, Anne B.
AU - Kritchevsky, Stephen B.
AU - Butler, Javed
PY - 2016
Y1 - 2016
N2 - Introduction: Data on the association between exercise capacity and risk for heart failure (HF) in older adults are limited. Methods: This study examined the association of exercise capacity, and its change over time, with 10-year mortality and incident HF in 2,935 participants of the Health, Aging, and Body Composition Study without HF at baseline (age, 73.6 [SD=2.9] years; 52.1% women; 41.4% black; 58.6% white). This cohort was initiated in 1997-1998 and exercise capacity was evaluated with a long-distance corridor walk test (LDCW) at baseline and Year 4. Outcomes were collected in 2007-2008 and initial analysis performed in 2014. Results: Ten-year incident HF for completers (n=2,245); non-completers (n=331); and those excluded from LDCW for safety reasons (n=359) was 11.4%, 19.2%, and 23.0%, respectively. The corresponding 10-year mortality was 27.9%, 41.1%, and 42.4%. In models accounting for competing mortality, the adjusted subhazard ratio for HF was 1.37 (95% CI=1.00, 1.88;. p=0.049) in non-completers and 1.41 (95% CI=1.06, 1.89;. p=0.020) in those excluded versus completers. Non-completers (adjusted hazard ratio, 1.49; 95% CI=1.21, 1.84;. p<0.001) and those excluded (hazard ratio, 1.27; 95% CI=1.04, 1.55;. p=0.016) had elevated mortality. In adjusted models, LDCW performance variables were associated mainly with mortality. Only 20-meter walking speed and resting heart rate retained prognostic value for HF. Longitudinal changes in LDCW did not predict subsequent incident HF or mortality. Conclusions: Completing an LDCW is strongly associated with lower 10-year mortality and HF risk in older adults. Therefore, walking capacity may serve as an early risk marker.
AB - Introduction: Data on the association between exercise capacity and risk for heart failure (HF) in older adults are limited. Methods: This study examined the association of exercise capacity, and its change over time, with 10-year mortality and incident HF in 2,935 participants of the Health, Aging, and Body Composition Study without HF at baseline (age, 73.6 [SD=2.9] years; 52.1% women; 41.4% black; 58.6% white). This cohort was initiated in 1997-1998 and exercise capacity was evaluated with a long-distance corridor walk test (LDCW) at baseline and Year 4. Outcomes were collected in 2007-2008 and initial analysis performed in 2014. Results: Ten-year incident HF for completers (n=2,245); non-completers (n=331); and those excluded from LDCW for safety reasons (n=359) was 11.4%, 19.2%, and 23.0%, respectively. The corresponding 10-year mortality was 27.9%, 41.1%, and 42.4%. In models accounting for competing mortality, the adjusted subhazard ratio for HF was 1.37 (95% CI=1.00, 1.88;. p=0.049) in non-completers and 1.41 (95% CI=1.06, 1.89;. p=0.020) in those excluded versus completers. Non-completers (adjusted hazard ratio, 1.49; 95% CI=1.21, 1.84;. p<0.001) and those excluded (hazard ratio, 1.27; 95% CI=1.04, 1.55;. p=0.016) had elevated mortality. In adjusted models, LDCW performance variables were associated mainly with mortality. Only 20-meter walking speed and resting heart rate retained prognostic value for HF. Longitudinal changes in LDCW did not predict subsequent incident HF or mortality. Conclusions: Completing an LDCW is strongly associated with lower 10-year mortality and HF risk in older adults. Therefore, walking capacity may serve as an early risk marker.
UR - http://www.scopus.com/inward/record.url?scp=85006823019&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006823019&partnerID=8YFLogxK
U2 - 10.1016/j.amepre.2016.08.041
DO - 10.1016/j.amepre.2016.08.041
M3 - Article
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
SN - 0749-3797
ER -