Einfluss der Tiefen Hirnstimulation des Nucleus subthalamicus auf exekutive Funktionen bei Patienten mit idiopathischem Parkinson-Syndrom unter Berücksichtigung von Apathie, Depressivität und Stimmung

U. Lueken; Y. Stankevich; T. Goschke; T. E. Schläpfer; J. Koy; H. Reichmann; A. Storch; M. Wolz

doi:10.1055/s-0034-1366460

Einfluss der Tiefen Hirnstimulation des Nucleus subthalamicus auf exekutive Funktionen bei Patienten mit idiopathischem Parkinson-Syndrom unter Berücksichtigung von Apathie, Depressivität und Stimmung

Translated title of the contribution: Executive task performance under deep brain stimulation of the subthalamic nucleus in Parkinson's disease revisited: The modulating influence of apathy, depression and mood

U. Lueken, Y. Stankevich, T. Goschke, T. E. Schläpfer, J. Koy, H. Reichmann, A. Storch, M. Wolz

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the moderating influence of apathy, depression and transient mood changes on executive functions under best medical treatment and under postoperative stimulation-on and -off conditions in a sample of 33 patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN), 33 PD patients with pharmacological treatment only and 34 healthy controls. In comparison to clinical and healthy control groups, DBS patients showed worse executive task performance and also more severe symptoms of depression and apathy. Apathy accounted for differences in stroop interference between groups. The effects of DBS on stroop interference were explained by increased state anxiety in the -off, so that DBS STN had no significant influence on test performance. Consideration of neuropsychiatric symptoms and acute mood changes is an important aspect when evaluating neuropsychological deficits in DBS patients.

Translated title of the contribution	Executive task performance under deep brain stimulation of the subthalamic nucleus in Parkinson's disease revisited: The modulating influence of apathy, depression and mood
Original language	German
Pages (from-to)	386-393
Number of pages	8
Journal	Fortschritte der Neurologie Psychiatrie
Volume	82
Issue number	7
DOIs	https://doi.org/10.1055/s-0034-1366460
State	Published - Jul 2014
Externally published	Yes

Keywords

Parkinson's disease
apathy
deep brain stimulation
depression
executive functions
subthalamic nucleus

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health

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Lueken, U., Stankevich, Y., Goschke, T., Schläpfer, T. E., Koy, J., Reichmann, H., Storch, A., & Wolz, M. (2014). Einfluss der Tiefen Hirnstimulation des Nucleus subthalamicus auf exekutive Funktionen bei Patienten mit idiopathischem Parkinson-Syndrom unter Berücksichtigung von Apathie, Depressivität und Stimmung. Fortschritte der Neurologie Psychiatrie, 82(7), 386-393. https://doi.org/10.1055/s-0034-1366460

Einfluss der Tiefen Hirnstimulation des Nucleus subthalamicus auf exekutive Funktionen bei Patienten mit idiopathischem Parkinson-Syndrom unter Berücksichtigung von Apathie, Depressivität und Stimmung. / Lueken, U.; Stankevich, Y.; Goschke, T.; Schläpfer, T. E.; Koy, J.; Reichmann, H.; Storch, A.; Wolz, M.

In: Fortschritte der Neurologie Psychiatrie, Vol. 82, No. 7, 07.2014, p. 386-393.

Research output: Contribution to journal › Article › peer-review

Lueken, U, Stankevich, Y, Goschke, T, Schläpfer, TE, Koy, J, Reichmann, H, Storch, A & Wolz, M 2014, 'Einfluss der Tiefen Hirnstimulation des Nucleus subthalamicus auf exekutive Funktionen bei Patienten mit idiopathischem Parkinson-Syndrom unter Berücksichtigung von Apathie, Depressivität und Stimmung', Fortschritte der Neurologie Psychiatrie, vol. 82, no. 7, pp. 386-393. https://doi.org/10.1055/s-0034-1366460

Lueken U, Stankevich Y, Goschke T, Schläpfer TE, Koy J, Reichmann H et al. Einfluss der Tiefen Hirnstimulation des Nucleus subthalamicus auf exekutive Funktionen bei Patienten mit idiopathischem Parkinson-Syndrom unter Berücksichtigung von Apathie, Depressivität und Stimmung. Fortschritte der Neurologie Psychiatrie. 2014 Jul;82(7):386-393. https://doi.org/10.1055/s-0034-1366460

Lueken, U. ; Stankevich, Y. ; Goschke, T. ; Schläpfer, T. E. ; Koy, J. ; Reichmann, H. ; Storch, A. ; Wolz, M. / Einfluss der Tiefen Hirnstimulation des Nucleus subthalamicus auf exekutive Funktionen bei Patienten mit idiopathischem Parkinson-Syndrom unter Berücksichtigung von Apathie, Depressivität und Stimmung. In: Fortschritte der Neurologie Psychiatrie. 2014 ; Vol. 82, No. 7. pp. 386-393.

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