Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

Scott L. Weiss; Mark J. Peters; Waleed Alhazzani; Michael S.D. Agus; Heidi R. Flori; David P. Inwald; Simon Nadel; Luregn J. Schlapbach; Robert C. Tasker; Andrew C. Argent; Joe Brierley; Joseph Carcillo; Enitan D. Carrol; Christopher L. Carroll; Ira M. Cheifetz; Karen Choong; Jeffry J. Cies; Andrea T. Cruz; Daniele De Luca; Akash Deep; Saul N. Faust; Claudio Flauzino De Oliveira; Mark W. Hall; Paul Ishimine; Etienne Javouhey; Koen F.M. Joosten; Poonam Joshi; Oliver Karam; Martin C.J. Kneyber; Joris Lemson; Graeme MacLaren; Nilesh M. Mehta; Morten Hylander Møller; Christopher J.L. Newth; Trung C. Nguyen; Akira Nishisaki; Mark E. Nunnally; Margaret M. Parker; Raina M. Paul; Adrienne G. Randolph; Suchitra Ranjit; Lewis H. Romer; Halden F. Scott; Lyvonne N. Tume; Judy T. Verger; Eric A. Williams; Joshua Wolf; Hector R. Wong; Jerry J. Zimmerman; Niranjan Kissoon; Pierre Tissieres

doi:10.1007/s00134-019-05877-7

Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

Scott L. Weiss, Mark J. Peters, Waleed Alhazzani, Michael S.D. Agus, Heidi R. Flori, David P. Inwald, Simon Nadel, Luregn J. Schlapbach, Robert C. Tasker, Andrew C. Argent, Joe Brierley, Joseph Carcillo, Enitan D. Carrol, Christopher L. Carroll, Ira M. Cheifetz, Karen Choong, Jeffry J. Cies, Andrea T. Cruz, Daniele De Luca, Akash DeepSaul N. Faust, Claudio Flauzino De Oliveira, Mark W. Hall, Paul Ishimine, Etienne Javouhey, Koen F.M. Joosten, Poonam Joshi, Oliver Karam, Martin C.J. Kneyber, Joris Lemson, Graeme MacLaren, Nilesh M. Mehta, Morten Hylander Møller, Christopher J.L. Newth, Trung C. Nguyen, Akira Nishisaki, Mark E. Nunnally, Margaret M. Parker, Raina M. Paul, Adrienne G. Randolph, Suchitra Ranjit, Lewis H. Romer, Halden F. Scott, Lyvonne N. Tume, Judy T. Verger, Eric A. Williams, Joshua Wolf, Hector R. Wong, Jerry J. Zimmerman, Niranjan Kissoon, Pierre Tissieres

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Original language	English (US)
Pages (from-to)	1-9
Number of pages	9
Journal	Intensive Care Medicine
Volume	46
DOIs	https://doi.org/10.1007/s00134-019-05877-7
State	Published - Feb 1 2020

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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10.1007/s00134-019-05877-7

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Weiss, S. L., Peters, M. J., Alhazzani, W., Agus, M. S. D., Flori, H. R., Inwald, D. P., Nadel, S., Schlapbach, L. J., Tasker, R. C., Argent, A. C., Brierley, J., Carcillo, J., Carrol, E. D., Carroll, C. L., Cheifetz, I. M., Choong, K., Cies, J. J., Cruz, A. T., De Luca, D., ... Tissieres, P. (2020). Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine, 46, 1-9. https://doi.org/10.1007/s00134-019-05877-7

Weiss, SL, Peters, MJ, Alhazzani, W, Agus, MSD, Flori, HR, Inwald, DP, Nadel, S, Schlapbach, LJ, Tasker, RC, Argent, AC, Brierley, J, Carcillo, J, Carrol, ED, Carroll, CL, Cheifetz, IM, Choong, K, Cies, JJ, Cruz, AT, De Luca, D, Deep, A, Faust, SN, De Oliveira, CF, Hall, MW, Ishimine, P, Javouhey, E, Joosten, KFM, Joshi, P, Karam, O, Kneyber, MCJ, Lemson, J, MacLaren, G, Mehta, NM, Møller, MH, Newth, CJL, Nguyen, TC, Nishisaki, A, Nunnally, ME, Parker, MM, Paul, RM, Randolph, AG, Ranjit, S, Romer, LH, Scott, HF, Tume, LN, Verger, JT, Williams, EA, Wolf, J, Wong, HR, Zimmerman, JJ, Kissoon, N & Tissieres, P 2020, 'Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children', Intensive Care Medicine, vol. 46, pp. 1-9. https://doi.org/10.1007/s00134-019-05877-7

@article{fd42d80d41e84cf3aa766ff2e781f8b7,

title = "Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children",

author = "Weiss, {Scott L.} and Peters, {Mark J.} and Waleed Alhazzani and Agus, {Michael S.D.} and Flori, {Heidi R.} and Inwald, {David P.} and Simon Nadel and Schlapbach, {Luregn J.} and Tasker, {Robert C.} and Argent, {Andrew C.} and Joe Brierley and Joseph Carcillo and Carrol, {Enitan D.} and Carroll, {Christopher L.} and Cheifetz, {Ira M.} and Karen Choong and Cies, {Jeffry J.} and Cruz, {Andrea T.} and {De Luca}, Daniele and Akash Deep and Faust, {Saul N.} and {De Oliveira}, {Claudio Flauzino} and Hall, {Mark W.} and Paul Ishimine and Etienne Javouhey and Joosten, {Koen F.M.} and Poonam Joshi and Oliver Karam and Kneyber, {Martin C.J.} and Joris Lemson and Graeme MacLaren and Mehta, {Nilesh M.} and M{\o}ller, {Morten Hylander} and Newth, {Christopher J.L.} and Nguyen, {Trung C.} and Akira Nishisaki and Nunnally, {Mark E.} and Parker, {Margaret M.} and Paul, {Raina M.} and Randolph, {Adrienne G.} and Suchitra Ranjit and Romer, {Lewis H.} and Scott, {Halden F.} and Tume, {Lyvonne N.} and Verger, {Judy T.} and Williams, {Eric A.} and Joshua Wolf and Wong, {Hector R.} and Zimmerman, {Jerry J.} and Niranjan Kissoon and Pierre Tissieres",

note = "Funding Information: Drs. Weiss and Peters served as arbiters for conflict interest management and adjudication throughout the guidelines process following standard operating procedures set forth by Society of Critical Care Medicine (SCCM) and endorsed by European Society of Intensive Care Medicine. Dr. Weiss participates in Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) and Shock Society. Dr. Peters participates in the UK PICS study group (vice-chair) and has testified as an expert witness in cases of clinical negligence, causation of injuries. Dr. Agus participates in the American Academy of Pediatrics, Pediatric Academic Societies, American Pediatric Society, Society for Pediatric Research, and The American Society for Clinical Investigation, and he has testified as an expert witness in cases related to ICU and/or endocrinology in children. Dr. Flori participates in American Thoracic Society (ATS) State Chapter (Executive Board Member—Michigan and California State Chapters) and PALISI Network (Steering committee member for various studies being implemented through the Network from intramural funding, governmental, or grant funding from Gerber Foundation). Dr. Nadel (past president) received funding from La Jolla Pharmaceutical (consulting), and he participates in the European Society of Pediatric and Neonatal Intensive Care Medicine (ESPNIC) (Medical President). Dr. Brierley (past president) participates in the ESPNIC. Dr. Carrol participates in NICE (Diagnostic Advisory Committee panel) and National Institutes for Health Research (two scientific panels, i4i and DTF). Dr. Cheifetz participates in American Association for Respiratory Care and ATS (volunteer activities) and has testified as an expert witness for medical malpractice cases, he is an advisor to Philips, and a contributor to Up-to-Date. Dr. Cies received funding from Allergan, Merck, Thermo Fisher Scientific, and Atlantic Diagnostic Laboratories (consultant), and he participates in Pediatric Pharmacy Advocacy Group (multiple positions), Society of Infectious Diseases Pharmacists (Vice-Chair of the Inter-organizations Liaison Committee), and the American College of Clinical Pharmacists (member and fellow). Dr. Cruz has provided testimony for legal cases involving children with tuberculosis-related meningitis and is an associate editor for Pediatrics. Dr. De Luca serves as Medical President-elect on the Executive Committee of ESPNIC, he served as a consultant and lecturer on the external advisory board and received research and educational grants from Chiesi Farmaceutici S.p.A and AbbVie, and travel grants from AbbVie, he has been a lecturer for Philips, Radiometer, and Waire. Dr. Faust served as chair of the UK NICE Guideline Committee for Sepsis in Children and Adults published in 2016 and for Lyme disease published in 2018, serves as a regional representative to the UK NHS England Clinical Reference Group for commissioning pediatric specialist medicine care (immunology and infection). Dr. Hall receives funding from La Jolla Pharmaceuticals (consultant on the data safety monitoring board for a clinical trial of a sepsis therapeutic), and he participates in the ATS (online journal club editor) and the American Board of Pediatrics (Critical Care Medicine sub-board). Dr. Ishimine participates in SAEM (Consensus Conference Co-Chair), American Board of Pediatrics/American Board of Emergency Medicine (Immediate Past Chair of the Pediatric Emergency Medicine Subboard), and the American College of Emergency Physicians (Pediatric Emergency Medicine Committee member). Dr. Javouhey received funding from CSL Behring (trial on Intravenous Immunoglobulins in toxic shock syndrome in children). Dr. Karam participates in BloodNet, PALISI, ISBT, AABB, and CCCTG. Dr. Kneyber participates in the ESPNIC. Dr. MacLaren participates in Extracorporeal Life Support Organization (Executive Committee). Dr. Mehta participates in the American Society for Parenteral and Enteral Nutrition (president). Dr. M{\o}ller participates in the Science Systems and Applications (board member). Dr. Newth received funding from Philips Research North America (consulting concerning monitoring in PICU), and he participates in the ATS. Dr. Nishisaki{\textquoteright}s institutional department receives an unrestricted grant from Nihon Kohden (involves an activity to develop a device to measure capillary refill time), and he participates in the Society for Simulation in Healthcare and International Society for Pediatric Simulation. Dr. Nunnally reports service on committees and board seats for the SCCM{\textquoteright}s American College of Critical Care Medicine (Regent), Society of Critical Care Anesthesiologists (director), the American Society of Anesthesiologists (committee), International Anesthesia Research Society, and NYSA. Dr. Randolph{\textquoteright}s institution received funding from Genentech (influenza biomarker study research support); she has received funding from Bristol Myers Squibb (consultant in 2017) and La Jolla Pharmaceuticals (design of pediatric septic shock trial of angiotensin II); and she participates in the ATS and the International Sepsis Forum. Dr. Ranjit participates as the Chancellor of College of Pediatric Critical Care, India. Dr. Tume participates in ESPNIC (Nursing President) and the UK PICS Scientific and Education Committee. Dr. Verger participates in the American Association of Critical-Care Nurses (Cert. Corp. Governance Committee) and the Academy of Nursing (Acute and Critical Care Special Interest Group). Dr. Williams participates in the Pediatric Cardiac Intensive Care Society. Dr. Wolf received funding support for participation in industry-sponsored research from Merck and Co, Astellas, and Cempra Pharmaceuticals, and he received other support from Karius, Empatica, and Bluespark Technologies. Dr. Zimmerman received funding from Immunexpress, Seattle and is Past President of SCCM (sepsis biomarker research), and he participates in the AAP and Pediatric Academic Society. Dr. Tissieres received funding from Baxter acute therapies, Bristol-Myers Squibb Company, Chiesi Farmaceutici S.p.A., Faron Pharmaceuticals (consulting, renal replacement therapy), and Biomerieux, funding from La Jolla Pharmaceuticals, Chiesi Farmaceutici S.p.A., and is President ESPNIC (research grant, biomarkers sepsis), and he participates in the Swiss Intensive Care Society, Swiss Pediatric Society, and the French Society of Intensive Care. The remaining authors have disclosed that they do not have any potential conflicts of interest. ",

year = "2020",

month = feb,

day = "1",

doi = "10.1007/s00134-019-05877-7",

language = "English (US)",

volume = "46",

pages = "1--9",

journal = "Intensive Care Medicine",

issn = "0342-4642",

publisher = "Springer Verlag",

}

TY - JOUR

T1 - Executive summary

T2 - surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

AU - Weiss, Scott L.

AU - Peters, Mark J.

AU - Alhazzani, Waleed

AU - Agus, Michael S.D.

AU - Flori, Heidi R.

AU - Inwald, David P.

AU - Nadel, Simon

AU - Schlapbach, Luregn J.

AU - Tasker, Robert C.

AU - Argent, Andrew C.

AU - Brierley, Joe

AU - Carcillo, Joseph

AU - Carrol, Enitan D.

AU - Carroll, Christopher L.

AU - Cheifetz, Ira M.

AU - Choong, Karen

AU - Cies, Jeffry J.

AU - Cruz, Andrea T.

AU - De Luca, Daniele

AU - Deep, Akash

AU - Faust, Saul N.

AU - De Oliveira, Claudio Flauzino

AU - Hall, Mark W.

AU - Ishimine, Paul

AU - Javouhey, Etienne

AU - Joosten, Koen F.M.

AU - Joshi, Poonam

AU - Karam, Oliver

AU - Kneyber, Martin C.J.

AU - Lemson, Joris

AU - MacLaren, Graeme

AU - Mehta, Nilesh M.

AU - Møller, Morten Hylander

AU - Newth, Christopher J.L.

AU - Nguyen, Trung C.

AU - Nishisaki, Akira

AU - Nunnally, Mark E.

AU - Parker, Margaret M.

AU - Paul, Raina M.

AU - Randolph, Adrienne G.

AU - Ranjit, Suchitra

AU - Romer, Lewis H.

AU - Scott, Halden F.

AU - Tume, Lyvonne N.

AU - Verger, Judy T.

AU - Williams, Eric A.

AU - Wolf, Joshua

AU - Wong, Hector R.

AU - Zimmerman, Jerry J.

AU - Kissoon, Niranjan

AU - Tissieres, Pierre

N1 - Funding Information: Drs. Weiss and Peters served as arbiters for conflict interest management and adjudication throughout the guidelines process following standard operating procedures set forth by Society of Critical Care Medicine (SCCM) and endorsed by European Society of Intensive Care Medicine. Dr. Weiss participates in Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) and Shock Society. Dr. Peters participates in the UK PICS study group (vice-chair) and has testified as an expert witness in cases of clinical negligence, causation of injuries. Dr. Agus participates in the American Academy of Pediatrics, Pediatric Academic Societies, American Pediatric Society, Society for Pediatric Research, and The American Society for Clinical Investigation, and he has testified as an expert witness in cases related to ICU and/or endocrinology in children. Dr. Flori participates in American Thoracic Society (ATS) State Chapter (Executive Board Member—Michigan and California State Chapters) and PALISI Network (Steering committee member for various studies being implemented through the Network from intramural funding, governmental, or grant funding from Gerber Foundation). Dr. Nadel (past president) received funding from La Jolla Pharmaceutical (consulting), and he participates in the European Society of Pediatric and Neonatal Intensive Care Medicine (ESPNIC) (Medical President). Dr. Brierley (past president) participates in the ESPNIC. Dr. Carrol participates in NICE (Diagnostic Advisory Committee panel) and National Institutes for Health Research (two scientific panels, i4i and DTF). Dr. Cheifetz participates in American Association for Respiratory Care and ATS (volunteer activities) and has testified as an expert witness for medical malpractice cases, he is an advisor to Philips, and a contributor to Up-to-Date. Dr. Cies received funding from Allergan, Merck, Thermo Fisher Scientific, and Atlantic Diagnostic Laboratories (consultant), and he participates in Pediatric Pharmacy Advocacy Group (multiple positions), Society of Infectious Diseases Pharmacists (Vice-Chair of the Inter-organizations Liaison Committee), and the American College of Clinical Pharmacists (member and fellow). Dr. Cruz has provided testimony for legal cases involving children with tuberculosis-related meningitis and is an associate editor for Pediatrics. Dr. De Luca serves as Medical President-elect on the Executive Committee of ESPNIC, he served as a consultant and lecturer on the external advisory board and received research and educational grants from Chiesi Farmaceutici S.p.A and AbbVie, and travel grants from AbbVie, he has been a lecturer for Philips, Radiometer, and Waire. Dr. Faust served as chair of the UK NICE Guideline Committee for Sepsis in Children and Adults published in 2016 and for Lyme disease published in 2018, serves as a regional representative to the UK NHS England Clinical Reference Group for commissioning pediatric specialist medicine care (immunology and infection). Dr. Hall receives funding from La Jolla Pharmaceuticals (consultant on the data safety monitoring board for a clinical trial of a sepsis therapeutic), and he participates in the ATS (online journal club editor) and the American Board of Pediatrics (Critical Care Medicine sub-board). Dr. Ishimine participates in SAEM (Consensus Conference Co-Chair), American Board of Pediatrics/American Board of Emergency Medicine (Immediate Past Chair of the Pediatric Emergency Medicine Subboard), and the American College of Emergency Physicians (Pediatric Emergency Medicine Committee member). Dr. Javouhey received funding from CSL Behring (trial on Intravenous Immunoglobulins in toxic shock syndrome in children). Dr. Karam participates in BloodNet, PALISI, ISBT, AABB, and CCCTG. Dr. Kneyber participates in the ESPNIC. Dr. MacLaren participates in Extracorporeal Life Support Organization (Executive Committee). Dr. Mehta participates in the American Society for Parenteral and Enteral Nutrition (president). Dr. Møller participates in the Science Systems and Applications (board member). Dr. Newth received funding from Philips Research North America (consulting concerning monitoring in PICU), and he participates in the ATS. Dr. Nishisaki’s institutional department receives an unrestricted grant from Nihon Kohden (involves an activity to develop a device to measure capillary refill time), and he participates in the Society for Simulation in Healthcare and International Society for Pediatric Simulation. Dr. Nunnally reports service on committees and board seats for the SCCM’s American College of Critical Care Medicine (Regent), Society of Critical Care Anesthesiologists (director), the American Society of Anesthesiologists (committee), International Anesthesia Research Society, and NYSA. Dr. Randolph’s institution received funding from Genentech (influenza biomarker study research support); she has received funding from Bristol Myers Squibb (consultant in 2017) and La Jolla Pharmaceuticals (design of pediatric septic shock trial of angiotensin II); and she participates in the ATS and the International Sepsis Forum. Dr. Ranjit participates as the Chancellor of College of Pediatric Critical Care, India. Dr. Tume participates in ESPNIC (Nursing President) and the UK PICS Scientific and Education Committee. Dr. Verger participates in the American Association of Critical-Care Nurses (Cert. Corp. Governance Committee) and the Academy of Nursing (Acute and Critical Care Special Interest Group). Dr. Williams participates in the Pediatric Cardiac Intensive Care Society. Dr. Wolf received funding support for participation in industry-sponsored research from Merck and Co, Astellas, and Cempra Pharmaceuticals, and he received other support from Karius, Empatica, and Bluespark Technologies. Dr. Zimmerman received funding from Immunexpress, Seattle and is Past President of SCCM (sepsis biomarker research), and he participates in the AAP and Pediatric Academic Society. Dr. Tissieres received funding from Baxter acute therapies, Bristol-Myers Squibb Company, Chiesi Farmaceutici S.p.A., Faron Pharmaceuticals (consulting, renal replacement therapy), and Biomerieux, funding from La Jolla Pharmaceuticals, Chiesi Farmaceutici S.p.A., and is President ESPNIC (research grant, biomarkers sepsis), and he participates in the Swiss Intensive Care Society, Swiss Pediatric Society, and the French Society of Intensive Care. The remaining authors have disclosed that they do not have any potential conflicts of interest.

PY - 2020/2/1

Y1 - 2020/2/1

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UR - http://www.scopus.com/inward/citedby.url?scp=85079081184&partnerID=8YFLogxK

U2 - 10.1007/s00134-019-05877-7

DO - 10.1007/s00134-019-05877-7

M3 - Article

C2 - 32030528

AN - SCOPUS:85079081184

SN - 0342-4642

VL - 46

SP - 1

EP - 9

JO - Intensive Care Medicine

JF - Intensive Care Medicine

ER -

Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

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