Executive function associated with sexual risk in young South African women: Findings from the HPTN 068 cohort

Molly Rosenberg, Audrey Pettifor, Mihaela Duta, Nele Demeyere, Ryan G. Wagner, Amanda Selin, Catherine MacPhail, Oliver Laeyendecker, James P. Hughes, Alan Stein, Stephen Tollman, Kathleen Kahn

Research output: Contribution to journalArticle

Abstract

Purpose Heightened sexual risk in adolescence and young adulthood may be partially explained by deficits in executive functioning, the set of cognitive processes used to make reasoned decisions. However, the association between executive function and sexual risk is understudied among adolescent girls and young women, particularly in low- and middle-income countries. Methods In a cohort of 853 young women age 18±25 in rural Mpumalanga province, South Africa, we evaluated executive function with three non-verbal cognitive tests: I. a rule-finding test, II. a trail-making test, and III. a figure drawing test. Using log-binomial regression models, we estimated the association between lower executive function test scores and indicators of sexual risk (unprotected sex acts, concurrent partnerships, transactional sex, and recent HSV-2 infection). Results In general, young women with lower executive function scores reported higher frequencies of sexual risk outcomes, though associations tended to be small with wide confidence intervals. Testing in the lowest quintile of Test I was associated with more unprotected sex [aPR 95% CI): 1.4 (1.0, 1.8)]. Testing in the lowest quintile of Test II was associated with more concurrent relationships and transactional sex [aPR (95% CI): 1.6 (1.1, 2.5) and 1.7 (1.3, 2.4), respectively], and testing in the lowest four quintiles of Test III was associated with more concurrent relationships [aPR (95% CI): 1.7 (1.0, 2.7)]. Conclusions These results demonstrate an association between low executive function and sexual risk in South African young women. Future work should seek to understand the nature of this association and whether there is promise in developing interventions to enhance executive function to reduce sexual risk.

Original languageEnglish (US)
Article numbere0195217
JournalPloS one
Volume13
Issue number4
DOIs
StatePublished - Apr 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Rosenberg, M., Pettifor, A., Duta, M., Demeyere, N., Wagner, R. G., Selin, A., MacPhail, C., Laeyendecker, O., Hughes, J. P., Stein, A., Tollman, S., & Kahn, K. (2018). Executive function associated with sexual risk in young South African women: Findings from the HPTN 068 cohort. PloS one, 13(4), [e0195217]. https://doi.org/10.1371/journal.pone.0195217