Executive and attention functioning among children in the PANDAS subgroup

Matthew E. Hirschtritt, Christopher Hammond, David Luckenbaugh, Jason Buhle, Audrey E. Thurm, B. J. Casey, Susan E. Swedo

Research output: Contribution to journalArticle

Abstract

Evidence from past studies indicates that adults and children with Obsessive-Compulsive Disorder (OCD) and Tourette syndrome (TS) experience subtle neuropsychological deficits. Less is known about neuropsychological functioning of children and adolescents with a symptom course consistent with the PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection) subgroup of OCD and tics. To provide such information, we administered three tests of attention control and two of executive function to 67 children and adolescents (ages 5-16) diagnosed with OCD and/or tics and a symptom course consistent with the PANDAS subgroup and 98 healthy volunteers (HV) matched by age, sex, and IQ. In a paired comparison of the two groups, the PANDAS subjects were less accurate than HV in a test of response suppression. Further, in a two-step linear regression analysis of the PANDAS group in which clinical variables were added stepwise into the model and in the second step matching variables (age, sex, and IQ) were added, IQ emerged as a predictor of performance on this task. In the same analysis, ADHD diagnosis and age emerged as predictors of response time in a continuous performance task. Subdividing the PANDAS group by primary psychiatric diagnosis revealed that subjects with TS or OCD with tics exhibited a longer response time compared to controls than subjects with OCD only, replicating previous findings within TS and OCD. This study demonstrates that children with PANDAS exhibit neuropsychological profiles similar to those of their primary psychiatric diagnosis.

Original languageEnglish (US)
Pages (from-to)179-194
Number of pages16
JournalChild Neuropsychology
Volume15
Issue number2
DOIs
StatePublished - Mar 2009
Externally publishedYes

Fingerprint

Obsessive-Compulsive Disorder
Tics
Tourette Syndrome
Task Performance and Analysis
Mental Disorders
Reaction Time
Healthy Volunteers
Matched-Pair Analysis
Executive Function
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections
Linear Models
Regression Analysis

Keywords

  • Attention
  • Executive functioning
  • Obsessive-compulsive disorder
  • PANDAS
  • Tourette syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Neuropsychology and Physiological Psychology

Cite this

Hirschtritt, M. E., Hammond, C., Luckenbaugh, D., Buhle, J., Thurm, A. E., Casey, B. J., & Swedo, S. E. (2009). Executive and attention functioning among children in the PANDAS subgroup. Child Neuropsychology, 15(2), 179-194. https://doi.org/10.1080/09297040802186899

Executive and attention functioning among children in the PANDAS subgroup. / Hirschtritt, Matthew E.; Hammond, Christopher; Luckenbaugh, David; Buhle, Jason; Thurm, Audrey E.; Casey, B. J.; Swedo, Susan E.

In: Child Neuropsychology, Vol. 15, No. 2, 03.2009, p. 179-194.

Research output: Contribution to journalArticle

Hirschtritt, ME, Hammond, C, Luckenbaugh, D, Buhle, J, Thurm, AE, Casey, BJ & Swedo, SE 2009, 'Executive and attention functioning among children in the PANDAS subgroup', Child Neuropsychology, vol. 15, no. 2, pp. 179-194. https://doi.org/10.1080/09297040802186899
Hirschtritt, Matthew E. ; Hammond, Christopher ; Luckenbaugh, David ; Buhle, Jason ; Thurm, Audrey E. ; Casey, B. J. ; Swedo, Susan E. / Executive and attention functioning among children in the PANDAS subgroup. In: Child Neuropsychology. 2009 ; Vol. 15, No. 2. pp. 179-194.
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