TY - JOUR
T1 - Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31
AU - Avramopoulos, Dimitris
AU - Kitsos, George
AU - Economou-Petersen, Effrosini
AU - Grigoriadou, Maria
AU - Vassilopoulos, Dimitris
AU - Papageorgiou, Constantinos
AU - Psilas, Konstantinos
AU - Petersen, Michael B.
PY - 1996
Y1 - 1996
N2 - A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data provide evidence that juvenile and adult onset POAG are genetically distinct disease entities.
AB - A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data provide evidence that juvenile and adult onset POAG are genetically distinct disease entities.
KW - Autosomal dominant
KW - Glaucoma
KW - Linkage analysis
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U2 - 10.1136/jmg.33.12.1043
DO - 10.1136/jmg.33.12.1043
M3 - Article
C2 - 9004141
AN - SCOPUS:0030468077
SN - 0022-2593
VL - 33
SP - 1043
EP - 1044
JO - Journal of medical genetics
JF - Journal of medical genetics
IS - 12
ER -