Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31

Dimitrios Avramopoulos, George Kitsos, Effrosini Economou-Petersen, Maria Grigoriadou, Dimitris Vassilopoulos, Constantinos Papageorgiou, Konstantinos Psilas, Michael B. Petersen

Research output: Contribution to journalArticle

Abstract

A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data provide evidence that juvenile and adult onset POAG are genetically distinct disease entities.

Original languageEnglish (US)
Pages (from-to)1043-1044
Number of pages2
JournalJournal of Medical Genetics
Volume33
Issue number12
StatePublished - 1996
Externally publishedYes

Fingerprint

Pedigree
Glaucoma
Chromosomes
Microsatellite Repeats
Primary Open Angle Glaucoma
Genes

Keywords

  • Autosomal dominant
  • Glaucoma
  • Linkage analysis

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Avramopoulos, D., Kitsos, G., Economou-Petersen, E., Grigoriadou, M., Vassilopoulos, D., Papageorgiou, C., ... Petersen, M. B. (1996). Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31. Journal of Medical Genetics, 33(12), 1043-1044.

Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31. / Avramopoulos, Dimitrios; Kitsos, George; Economou-Petersen, Effrosini; Grigoriadou, Maria; Vassilopoulos, Dimitris; Papageorgiou, Constantinos; Psilas, Konstantinos; Petersen, Michael B.

In: Journal of Medical Genetics, Vol. 33, No. 12, 1996, p. 1043-1044.

Research output: Contribution to journalArticle

Avramopoulos, D, Kitsos, G, Economou-Petersen, E, Grigoriadou, M, Vassilopoulos, D, Papageorgiou, C, Psilas, K & Petersen, MB 1996, 'Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31', Journal of Medical Genetics, vol. 33, no. 12, pp. 1043-1044.
Avramopoulos, Dimitrios ; Kitsos, George ; Economou-Petersen, Effrosini ; Grigoriadou, Maria ; Vassilopoulos, Dimitris ; Papageorgiou, Constantinos ; Psilas, Konstantinos ; Petersen, Michael B. / Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31. In: Journal of Medical Genetics. 1996 ; Vol. 33, No. 12. pp. 1043-1044.
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