Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31

Dimitris Avramopoulos, George Kitsos, Effrosini Economou-Petersen, Maria Grigoriadou, Dimitris Vassilopoulos, Constantinos Papageorgiou, Konstantinos Psilas, Michael B. Petersen

Research output: Contribution to journalArticlepeer-review

Abstract

A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data provide evidence that juvenile and adult onset POAG are genetically distinct disease entities.

Original languageEnglish (US)
Pages (from-to)1043-1044
Number of pages2
JournalJournal of medical genetics
Volume33
Issue number12
DOIs
StatePublished - 1996

Keywords

  • Autosomal dominant
  • Glaucoma
  • Linkage analysis

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31'. Together they form a unique fingerprint.

Cite this