Exclusion of linkage between familial Mediterranean fever and the human serum amyloid A (SAA) gene cluster

George H. Sack; C. Conover Talbot; Bruce G. McCarthy; Emily L. Harris; Daniel Kastner; Luis Gruberg; Mordechai Pras

doi:10.1007/BF00197178

Exclusion of linkage between familial Mediterranean fever and the human serum amyloid A (SAA) gene cluster

George H. Sack, C. Conover Talbot, Bruce G. McCarthy, Emily L. Harris, Daniel Kastner, Luis Gruberg, Mordechai Pras

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the relationship between the autosomal recessive trait familial Mediterranean fever (FMF) and the serum amyloid A (SAA) genes by comparing alleles of a highly polymorphic dinucleotide repeat and a conventional restriction fragment length polymorphism (RFLP) in the SAA gene cluster in Israeli FMF kindreds. By haplotype analysis, our data indicate a minimum crossover frequency of 22% between the SAA gene marker and FMF. By conventional linkage analysis this eliminates a minimum of 10.4cM including and surrounding the SAA gene cluster as the site of the FMF mutation although SAA proteins are prominent physiologic markers of the acute attacks.

Original language	English (US)
Pages (from-to)	506-508
Number of pages	3
Journal	Human genetics
Volume	87
Issue number	4
DOIs	https://doi.org/10.1007/BF00197178
State	Published - Aug 1 1991

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Exclusion of linkage between familial Mediterranean fever and the human serum amyloid A (SAA) gene cluster",

abstract = "We studied the relationship between the autosomal recessive trait familial Mediterranean fever (FMF) and the serum amyloid A (SAA) genes by comparing alleles of a highly polymorphic dinucleotide repeat and a conventional restriction fragment length polymorphism (RFLP) in the SAA gene cluster in Israeli FMF kindreds. By haplotype analysis, our data indicate a minimum crossover frequency of 22% between the SAA gene marker and FMF. By conventional linkage analysis this eliminates a minimum of 10.4cM including and surrounding the SAA gene cluster as the site of the FMF mutation although SAA proteins are prominent physiologic markers of the acute attacks.",

author = "Sack, {George H.} and Talbot, {C. Conover} and McCarthy, {Bruce G.} and Harris, {Emily L.} and Daniel Kastner and Luis Gruberg and Mordechai Pras",

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AU - Sack, George H.

AU - Talbot, C. Conover

AU - McCarthy, Bruce G.

AU - Harris, Emily L.

AU - Kastner, Daniel

AU - Gruberg, Luis

AU - Pras, Mordechai

PY - 1991/8/1

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