Exclusion of linkage between familial Mediterranean fever and the human serum amyloid A (SAA) gene cluster

George H. Sack, C. Conover Talbot, Bruce G. McCarthy, Emily L. Harris, Daniel Kastner, Luis Gruberg, Mordechai Pras

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the relationship between the autosomal recessive trait familial Mediterranean fever (FMF) and the serum amyloid A (SAA) genes by comparing alleles of a highly polymorphic dinucleotide repeat and a conventional restriction fragment length polymorphism (RFLP) in the SAA gene cluster in Israeli FMF kindreds. By haplotype analysis, our data indicate a minimum crossover frequency of 22% between the SAA gene marker and FMF. By conventional linkage analysis this eliminates a minimum of 10.4cM including and surrounding the SAA gene cluster as the site of the FMF mutation although SAA proteins are prominent physiologic markers of the acute attacks.

Original languageEnglish (US)
Pages (from-to)506-508
Number of pages3
JournalHuman genetics
Volume87
Issue number4
DOIs
StatePublished - Aug 1 1991

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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