Exclusion of close linkage between the synaptic vesicular monoamine transporter locus and schizophrenia spectrum disorders

A. M. Persico, Wu Wang Zhe Wu Wang, D. W. Black, N. C. Andreasen, G. R. Uhl, R. R. Crowe

Research output: Contribution to journalArticle

Abstract

The principal brain synaptic vesicular monoamine transporter (VMAT2) is responsible for the reuptake of serotonin, dopamine, norepinephrine, epinephrine, and histamine from the cytoplasm into synaptic vesicles, thus contributing to determination of the size of releasable neurotransmitter vesicular pools. Potential involvement of VMAT2 gene variants in the etiology of schizophrenia and related disorders was tested using polymorphic VMAT2 gene markers in 156 subjects from 16 multiplex pedigrees with schizophrenia, schizophreniform, schizoaffective, and schizotypal disorders and mood incongruent psychotic depression. Assuming genetic homogeneity, complete (Θ = 0.0) linkage to the schizophrenia spectrum was excluded under both dominant and recessive models. Allelic variants at the VMAT2 locus do not appear to provide major genetic contributions to the etiology of schizophrenia spectrum disorders in these pedigrees.

Original languageEnglish (US)
Pages (from-to)563-565
Number of pages3
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume60
Issue number6
DOIs
StatePublished - 1995

Fingerprint

Vesicular Monoamine Transport Proteins
Schizophrenia
Pedigree
Synaptic Vesicles
Psychotic Disorders
Histamine
Epinephrine
Genes
Neurotransmitter Agents
Dopamine
Serotonin
Norepinephrine
Cytoplasm
Depression
Brain

Keywords

  • dopamine
  • epinephrine
  • histamine
  • norepinephrine
  • serotonin

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Exclusion of close linkage between the synaptic vesicular monoamine transporter locus and schizophrenia spectrum disorders. / Persico, A. M.; Zhe Wu Wang, Wu Wang; Black, D. W.; Andreasen, N. C.; Uhl, G. R.; Crowe, R. R.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 60, No. 6, 1995, p. 563-565.

Research output: Contribution to journalArticle

Persico, A. M. ; Zhe Wu Wang, Wu Wang ; Black, D. W. ; Andreasen, N. C. ; Uhl, G. R. ; Crowe, R. R. / Exclusion of close linkage between the synaptic vesicular monoamine transporter locus and schizophrenia spectrum disorders. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 1995 ; Vol. 60, No. 6. pp. 563-565.
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