Exclusion of clinically atypical or microbiologically mixed diarrhoeal episodes from outcome events in a field trial of oral cholera vaccines

John D. Clemens, Bonita F. Stanton, Jeffrey R. Harris, J. Chakraborty, David A. Sack, Malla R. Rao, Faruque Ahmed, M. Ansaruzzaman, Md Yunus, Ann Mari Svennerholm, Jan Holmgren

Research output: Contribution to journalArticle

Abstract

Clemens J D (International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh), Stanton B F, Harris J R, Chakraborty J, Sack D A, Rao M R, Ahmed F, Ansaruzzaman M, Yunus M, Svennerholm A M and Holmgren J. Exclusion of clinically atypical or microbiologically mixed diarrhoeal episodes from outcome events in a field trial of oral cholera vaccines. International Journal of Epidemiology 1989, 18: 441-445.We investigated whether alternative clinical and microbiological criteria for outcome events affected estimates of vaccine efficacy in a randomized, double-blind field trial of B subunit-killed whole cell (BS-WC) and killed whole cell-only (WC) oral cholera vaccines among 62285 rural Bangladeshi participants. At one year of follow-up estimates of vaccine protective efficacy (PE = 60%, P

Original languageEnglish (US)
Pages (from-to)440-445
Number of pages6
JournalInternational Journal of Epidemiology
Volume18
Issue number2
DOIs
StatePublished - Jun 1989
Externally publishedYes

Fingerprint

Cholera Vaccines
Vaccine Efficacy
Vaccines
Bangladesh
Vaccine
Cell
Epidemiology
Estimate
Alternatives
Research
Cholera
Field trial
Exclusion

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Epidemiology

Cite this

Exclusion of clinically atypical or microbiologically mixed diarrhoeal episodes from outcome events in a field trial of oral cholera vaccines. / Clemens, John D.; Stanton, Bonita F.; Harris, Jeffrey R.; Chakraborty, J.; Sack, David A.; Rao, Malla R.; Ahmed, Faruque; Ansaruzzaman, M.; Yunus, Md; Svennerholm, Ann Mari; Holmgren, Jan.

In: International Journal of Epidemiology, Vol. 18, No. 2, 06.1989, p. 440-445.

Research output: Contribution to journalArticle

Clemens, JD, Stanton, BF, Harris, JR, Chakraborty, J, Sack, DA, Rao, MR, Ahmed, F, Ansaruzzaman, M, Yunus, M, Svennerholm, AM & Holmgren, J 1989, 'Exclusion of clinically atypical or microbiologically mixed diarrhoeal episodes from outcome events in a field trial of oral cholera vaccines', International Journal of Epidemiology, vol. 18, no. 2, pp. 440-445. https://doi.org/10.1093/ije/18.2.440
Clemens, John D. ; Stanton, Bonita F. ; Harris, Jeffrey R. ; Chakraborty, J. ; Sack, David A. ; Rao, Malla R. ; Ahmed, Faruque ; Ansaruzzaman, M. ; Yunus, Md ; Svennerholm, Ann Mari ; Holmgren, Jan. / Exclusion of clinically atypical or microbiologically mixed diarrhoeal episodes from outcome events in a field trial of oral cholera vaccines. In: International Journal of Epidemiology. 1989 ; Vol. 18, No. 2. pp. 440-445.
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