Exclusion of Autosomal Dominant Polycystic Kidney Disease type II (ADPKD2) from 160 cM of chromosome 1

Shrawan Kumar, William J. Kimberling, Patricia A. Gabow, Yin Y. Shugart, Sandra Pieke-Dahl

Research output: Contribution to journalArticle

Abstract

Autosomal dominant polycystic kidney disease is a heritable disorder and recent studies have shown genetic heterogeneity, with some, but not all, families showing linkage with markers on chromosome 16p. Members of a large ADPKD family, unlinked to chromosome 16, have been typed for 12 marker loci located on both arms of chromosome 1. Multipoint analysis excluded ADPKD2 from the region between D1S81 (pTHH33) and D1S67 (pHHH106) on the long arm and between Rh and PGM1 on the short arm. This excludes the disease locus from about 61% of chromosome 1.

Original languageEnglish (US)
Pages (from-to)697-700
Number of pages4
JournalJournal of Medical Genetics
Volume27
Issue number11
StatePublished - Nov 1990
Externally publishedYes

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Autosomal Dominant Polycystic Kidney
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 16
Genetic Heterogeneity
Genetic Markers

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Kumar, S., Kimberling, W. J., Gabow, P. A., Shugart, Y. Y., & Pieke-Dahl, S. (1990). Exclusion of Autosomal Dominant Polycystic Kidney Disease type II (ADPKD2) from 160 cM of chromosome 1. Journal of Medical Genetics, 27(11), 697-700.

Exclusion of Autosomal Dominant Polycystic Kidney Disease type II (ADPKD2) from 160 cM of chromosome 1. / Kumar, Shrawan; Kimberling, William J.; Gabow, Patricia A.; Shugart, Yin Y.; Pieke-Dahl, Sandra.

In: Journal of Medical Genetics, Vol. 27, No. 11, 11.1990, p. 697-700.

Research output: Contribution to journalArticle

Kumar, S, Kimberling, WJ, Gabow, PA, Shugart, YY & Pieke-Dahl, S 1990, 'Exclusion of Autosomal Dominant Polycystic Kidney Disease type II (ADPKD2) from 160 cM of chromosome 1', Journal of Medical Genetics, vol. 27, no. 11, pp. 697-700.
Kumar S, Kimberling WJ, Gabow PA, Shugart YY, Pieke-Dahl S. Exclusion of Autosomal Dominant Polycystic Kidney Disease type II (ADPKD2) from 160 cM of chromosome 1. Journal of Medical Genetics. 1990 Nov;27(11):697-700.
Kumar, Shrawan ; Kimberling, William J. ; Gabow, Patricia A. ; Shugart, Yin Y. ; Pieke-Dahl, Sandra. / Exclusion of Autosomal Dominant Polycystic Kidney Disease type II (ADPKD2) from 160 cM of chromosome 1. In: Journal of Medical Genetics. 1990 ; Vol. 27, No. 11. pp. 697-700.
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