Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: A retrospective cohort study of 137 children with sickle cell anemia

Monica L. Hulbert; Douglas J. Scothorn; Julie A. Panepinto; J. Paul Scott; George R. Buchanan; Sharada Sarnaik; Robert Fallon; Jen Yih Chu; Winfred Wang; James F. Casella; Linda Resar; Brian Berman; Thomas Adamkiewicz; Lewis L. Hsu; Kimberly Smith-Whitley; Donald Mahoney; Gerald Woods; Masayo Watanabe; Michael R. DeBaun

doi:10.1016/j.jpeds.2006.06.037

Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: A retrospective cohort study of 137 children with sickle cell anemia

Monica L. Hulbert, Douglas J. Scothorn, Julie A. Panepinto, J. Paul Scott, George R. Buchanan, Sharada Sarnaik, Robert Fallon, Jen Yih Chu, Winfred Wang, James F. Casella, Linda Resar, Brian Berman, Thomas Adamkiewicz, Lewis L. Hsu, Kimberly Smith-Whitley, Donald Mahoney, Gerald Woods, Masayo Watanabe, Michael R. DeBaun

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

A retrospective cohort study of children with sickle cell anemia (SCA) and strokes was used to test the hypothesis that exchange transfusion at the time of stroke presentation more effectively prevents second strokes than does simple transfusion. Children receiving simple transfusion had a 5-fold greater relative risk (95% confidence interval = 1.3 to 18.6) of second stroke than those receiving exchange transfusion.

Original language	English (US)
Pages (from-to)	710-712
Number of pages	3
Journal	Journal of Pediatrics
Volume	149
Issue number	5
DOIs	https://doi.org/10.1016/j.jpeds.2006.06.037
State	Published - Nov 2006
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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Hulbert, M. L., Scothorn, D. J., Panepinto, J. A., Scott, J. P., Buchanan, G. R., Sarnaik, S., Fallon, R., Chu, J. Y., Wang, W., Casella, J. F., Resar, L., Berman, B., Adamkiewicz, T., Hsu, L. L., Smith-Whitley, K., Mahoney, D., Woods, G., Watanabe, M., & DeBaun, M. R. (2006). Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: A retrospective cohort study of 137 children with sickle cell anemia. Journal of Pediatrics, 149(5), 710-712. https://doi.org/10.1016/j.jpeds.2006.06.037

Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke : A retrospective cohort study of 137 children with sickle cell anemia. / Hulbert, Monica L.; Scothorn, Douglas J.; Panepinto, Julie A. et al.

In: Journal of Pediatrics, Vol. 149, No. 5, 11.2006, p. 710-712.

Research output: Contribution to journal › Article › peer-review

Hulbert, ML, Scothorn, DJ, Panepinto, JA, Scott, JP, Buchanan, GR, Sarnaik, S, Fallon, R, Chu, JY, Wang, W, Casella, JF , Resar, L, Berman, B, Adamkiewicz, T, Hsu, LL, Smith-Whitley, K, Mahoney, D, Woods, G, Watanabe, M & DeBaun, MR 2006, 'Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: A retrospective cohort study of 137 children with sickle cell anemia', Journal of Pediatrics, vol. 149, no. 5, pp. 710-712. https://doi.org/10.1016/j.jpeds.2006.06.037

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title = "Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: A retrospective cohort study of 137 children with sickle cell anemia",

abstract = "A retrospective cohort study of children with sickle cell anemia (SCA) and strokes was used to test the hypothesis that exchange transfusion at the time of stroke presentation more effectively prevents second strokes than does simple transfusion. Children receiving simple transfusion had a 5-fold greater relative risk (95% confidence interval = 1.3 to 18.6) of second stroke than those receiving exchange transfusion.",

author = "Hulbert, {Monica L.} and Scothorn, {Douglas J.} and Panepinto, {Julie A.} and Scott, {J. Paul} and Buchanan, {George R.} and Sharada Sarnaik and Robert Fallon and Chu, {Jen Yih} and Winfred Wang and Casella, {James F.} and Linda Resar and Brian Berman and Thomas Adamkiewicz and Hsu, {Lewis L.} and Kimberly Smith-Whitley and Donald Mahoney and Gerald Woods and Masayo Watanabe and DeBaun, {Michael R.}",

year = "2006",

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doi = "10.1016/j.jpeds.2006.06.037",

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AU - Buchanan, George R.

AU - Sarnaik, Sharada

AU - Fallon, Robert

AU - Chu, Jen Yih

AU - Wang, Winfred

AU - Casella, James F.

AU - Resar, Linda

AU - Berman, Brian

AU - Adamkiewicz, Thomas

AU - Hsu, Lewis L.

AU - Smith-Whitley, Kimberly

AU - Mahoney, Donald

AU - Woods, Gerald

AU - Watanabe, Masayo

AU - DeBaun, Michael R.

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Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: A retrospective cohort study of 137 children with sickle cell anemia

Abstract

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