Excessive daytime sleepiness and napping in cognitively normal adults: Associations with subsequent amyloid deposition measured by PiB PET

Adam P. Spira, Yang An, Mark N. Wu, Jocelynn T. Owusu, Eleanor M. Simonsick, Murat Bilgel, Luigi Ferrucci, Dean F. Wong, Susan M. Resnick

Research output: Contribution to journalArticlepeer-review

Abstract

Study Objectives To determine the association of excessive daytime sleepiness (EDS) and napping with subsequent brain β-amyloid (Aβ) deposition in cognitively normal persons. Methods We studied 124 community-dwelling participants in the Baltimore Longitudinal Study of Aging Neuroimaging Substudy who completed self-report measures of EDS and napping at our study baseline and underwent [ 11 C] Pittsburgh compound B positron emission tomography (PiB PET) scans of the brain, an average ±standard deviation of 15.7 ± 3.4 years later (range 6.9 to 24.6). Scans with a cortical distribution volume ratio of >1.06 were considered Aβ-positive. Results Participants were aged 60.1 ± 9.8 years (range 36.2 to 82.7) at study baseline; 24.4% had EDS and 28.5% napped. In unadjusted analyses, compared with participants without EDS, those with EDS had more than 3 times the odds of being Aβ+ at follow-up (odds ratio [OR] = 3.37, 95% confidence interval [CI]: 1.44, 7.90, p = 0.005), and 2.75 times the odds after adjustment for age, age 2, sex, education, and body mass index (OR = 2.75, 95% CI: 1.09, 6.95, p = 0.033). There was a trend-level unadjusted association between napping and Aβ status (OR = 2.01, 95% CI: 0.90, 4.50, p = 0.091) that became nonsignificant after adjustment (OR = 1.86, 95% CI: 0.73, 4.75, p = 0.194). Conclusions EDS is associated with more than 2.5 times the odds of Aβ deposition an average of 15.7 years later. If common EDS causes (e.g., sleep-disordered breathing, insufficient sleep) are associated with temporally distal AD biomarkers, this could have important implications for AD prevention.

Original languageEnglish (US)
JournalSleep
Volume41
Issue number10
DOIs
StatePublished - Oct 1 2018

Keywords

  • aging
  • biomarkers
  • brain imaging
  • epidemiology
  • napping
  • neurological disorders
  • sleepiness

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)

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