Exception-Status Listing: A Critical Pathway to Heart Transplantation for Adults With Congenital Heart Diseases

ANIKET S. Rali; SAGAR RANKA; JEREMY A. MAZUREK; MARSHALL D. BRINKLEY; A. R.I. CEDARS; DANIEL CLARK; N. H.U.E. DO; GINA E. LAZZARA; L. Y.N.N. PUNNOOSE; EMILY SANDHAUS; ASHISH SHAH; S. I.V.A. TADURU; M. A.R.K. WIGGER; SANDIP ZALAWADIYA; JOSEPH ROGERS; JOANN LINDENFELD; KELLY SCHLENDORF; JONATHAN N. MENACHEM

doi:10.1016/j.cardfail.2021.10.004

Exception-Status Listing: A Critical Pathway to Heart Transplantation for Adults With Congenital Heart Diseases

ANIKET S. Rali, SAGAR RANKA, JEREMY A. MAZUREK, MARSHALL D. BRINKLEY, A. R.I. CEDARS, DANIEL CLARK, N. H.U.E. DO, GINA E. LAZZARA, L. Y.N.N. PUNNOOSE, EMILY SANDHAUS, ASHISH SHAH, S. I.V.A. TADURU, M. A.R.K. WIGGER, SANDIP ZALAWADIYA, JOSEPH ROGERS, JOANN LINDENFELD, KELLY SCHLENDORF, JONATHAN N. MENACHEM

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Adults with congenital heart diseases may not be candidates for conventional therapies to control ventricular systolic dysfunction, including mechanical circulatory support, which moves potential heart-transplantation recipients to a listing status of higher priority. This results in longer waitlist times and greater mortality rates. Exception-status listing allows a pathway for this complex and anatomically heterogenous group of patients to be listed for heart transplantation at appropriately high listing status. Our study queried the United Network for Organ Sharing registry to evaluate trends in the use of exception-status listing among adults with congenital heart diseases awaiting heart transplantation. Uptrend in the use of exception-status listing precedes the new allocation system, but it has been greatest since changes were made in the allocation system. It continues to remain a vital pathway for adults with congenital heart disease (whose waitlist mortality rates are often not characterized adequately by using the waitlist-status criteria) timely access to heart transplantation.

Original language	English (US)
Pages (from-to)	415-421
Number of pages	7
Journal	Journal of cardiac failure
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/j.cardfail.2021.10.004
State	Published - Mar 2022

Keywords

Heart transplantation allocation system
adults with congenital heart disease
exception-status listing
heart transplantation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.cardfail.2021.10.004

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Rali, ANIKET. S., RANKA, SAGAR., MAZUREK, JEREMY. A., BRINKLEY, MARSHALL. D., CEDARS, A. R. I., CLARK, DANIEL., DO, N. H. U. E., LAZZARA, GINA. E., PUNNOOSE, L. Y. N. N., SANDHAUS, EMILY., SHAH, ASHISH., TADURU, S. I. V. A., WIGGER, M. A. R. K., ZALAWADIYA, SANDIP., ROGERS, JOSEPH., LINDENFELD, JOANN., SCHLENDORF, KELLY., & MENACHEM, JONATHAN. N. (2022). Exception-Status Listing: A Critical Pathway to Heart Transplantation for Adults With Congenital Heart Diseases. Journal of cardiac failure, 28(3), 415-421. https://doi.org/10.1016/j.cardfail.2021.10.004

Rali, ANIKETS, RANKA, SAGAR, MAZUREK, JEREMYA, BRINKLEY, MARSHALLD, CEDARS, ARI, CLARK, DANIEL, DO, NHUE, LAZZARA, GINAE, PUNNOOSE, LYNN, SANDHAUS, EMILY, SHAH, ASHISH, TADURU, SIVA, WIGGER, MARK, ZALAWADIYA, SANDIP, ROGERS, JOSEPH, LINDENFELD, JOANN, SCHLENDORF, KELLY & MENACHEM, JONATHANN 2022, 'Exception-Status Listing: A Critical Pathway to Heart Transplantation for Adults With Congenital Heart Diseases', Journal of cardiac failure, vol. 28, no. 3, pp. 415-421. https://doi.org/10.1016/j.cardfail.2021.10.004

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abstract = "Adults with congenital heart diseases may not be candidates for conventional therapies to control ventricular systolic dysfunction, including mechanical circulatory support, which moves potential heart-transplantation recipients to a listing status of higher priority. This results in longer waitlist times and greater mortality rates. Exception-status listing allows a pathway for this complex and anatomically heterogenous group of patients to be listed for heart transplantation at appropriately high listing status. Our study queried the United Network for Organ Sharing registry to evaluate trends in the use of exception-status listing among adults with congenital heart diseases awaiting heart transplantation. Uptrend in the use of exception-status listing precedes the new allocation system, but it has been greatest since changes were made in the allocation system. It continues to remain a vital pathway for adults with congenital heart disease (whose waitlist mortality rates are often not characterized adequately by using the waitlist-status criteria) timely access to heart transplantation.",

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note = "Funding Information: The authors thank the Brett Boyer Foundation and the Pete Huttlinger Fund for Adult Congenital Cardiac Research for their continued support and dedication to improving outcomes for those with CHD. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

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AU - BRINKLEY, MARSHALL D.

AU - CEDARS, A. R.I.

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AU - LAZZARA, GINA E.

AU - PUNNOOSE, L. Y.N.N.

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AU - SHAH, ASHISH

AU - TADURU, S. I.V.A.

AU - WIGGER, M. A.R.K.

AU - ZALAWADIYA, SANDIP

AU - ROGERS, JOSEPH

AU - LINDENFELD, JOANN

AU - SCHLENDORF, KELLY

AU - MENACHEM, JONATHAN N.

N1 - Funding Information: The authors thank the Brett Boyer Foundation and the Pete Huttlinger Fund for Adult Congenital Cardiac Research for their continued support and dedication to improving outcomes for those with CHD. Publisher Copyright: © 2021 Elsevier Inc.

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Exception-Status Listing: A Critical Pathway to Heart Transplantation for Adults With Congenital Heart Diseases

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Keywords

ASJC Scopus subject areas

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