Examining the utility of patient-derived xenograft mouse models

Samuel Aparicio, Manuel Hidalgo, Andrew L. Kung

Research output: Contribution to journalReview articlepeer-review


Patient-derived xenograft (PDX) models are now being widely used in cancer research and have the potential to greatly inform our understanding of cancer biology. However, many questions remain, especially regarding the ability of PDX models to affect clinical decision making. With these points in mind, we asked three scientists to give their opinions on the generation and uses of PDX models and the future of this field.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalNature Reviews Cancer
Issue number5
StatePublished - Apr 24 2015

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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