Examining Nitroxyl in Biological Systems

Jon M. Fukuto, Matthew I. Jackson, Nina Kaludercic, Nazareno Paolocci

Research output: Contribution to journalArticle

Abstract

Nitroxyl (HNO) has received significant recent attention due to its remarkable and novel biological activity and pharmacological potential. Unlike most other commonly studied nitrogen oxides, examination of HNO biology is not straightforward because of its unique chemical properties. Thus, the study of HNO in biological system requires researchers to be aware of this chemistry in order to properly design and interpret experiments. This chapter focuses on the experimental issues associated with the study of HNO and attempts to provide guidelines for working with this novel and fascinating nitrogen oxide.

Original languageEnglish (US)
Pages (from-to)411-431
Number of pages21
JournalMethods in Enzymology
Volume440
DOIs
StatePublished - 2008

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Nitrogen Oxides
Biological systems
Bioactivity
Chemical properties
Nitric Oxide
Research Personnel
Pharmacology
Guidelines
Experiments
nitroxyl

ASJC Scopus subject areas

  • Biochemistry

Cite this

Examining Nitroxyl in Biological Systems. / Fukuto, Jon M.; Jackson, Matthew I.; Kaludercic, Nina; Paolocci, Nazareno.

In: Methods in Enzymology, Vol. 440, 2008, p. 411-431.

Research output: Contribution to journalArticle

Fukuto, Jon M. ; Jackson, Matthew I. ; Kaludercic, Nina ; Paolocci, Nazareno. / Examining Nitroxyl in Biological Systems. In: Methods in Enzymology. 2008 ; Vol. 440. pp. 411-431.
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