Examining Nitroxyl in Biological Systems

Jon M. Fukuto, Matthew I. Jackson, Nina Kaludercic, Nazareno Paolocci

Research output: Chapter in Book/Report/Conference proceedingChapter


Nitroxyl (HNO) has received significant recent attention due to its remarkable and novel biological activity and pharmacological potential. Unlike most other commonly studied nitrogen oxides, examination of HNO biology is not straightforward because of its unique chemical properties. Thus, the study of HNO in biological system requires researchers to be aware of this chemistry in order to properly design and interpret experiments. This chapter focuses on the experimental issues associated with the study of HNO and attempts to provide guidelines for working with this novel and fascinating nitrogen oxide.

Original languageEnglish (US)
Title of host publicationNitric Oxide, Part F
EditorsEnrique Cadenas, Lester Packer
Number of pages21
StatePublished - Sep 24 2008

Publication series

NameMethods in Enzymology
ISSN (Print)0076-6879

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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  • Cite this

    Fukuto, J. M., Jackson, M. I., Kaludercic, N., & Paolocci, N. (2008). Examining Nitroxyl in Biological Systems. In E. Cadenas, & L. Packer (Eds.), Nitric Oxide, Part F (pp. 411-431). (Methods in Enzymology; Vol. 440). https://doi.org/10.1016/S0076-6879(07)00826-9