Exaggerated vasopressor response to exercise and cerebral blood flow velocity

Vernon Bond, Richard M. Millis, Alfonso Campbell, Jules Harrell, Kim L. Goring, Inez Reeves, Sheree M. Johnson, Richard G. Adams

Research output: Contribution to journalArticlepeer-review

Abstract

We studied 10 young adults, normotensive at rest, comprising a control group (n 5) with normal blood pressure responsiveness to exercise and an experimental group exhibiting greater percentage of body fat and body mass index (BMI) than the controls, with exaggerated blood pressure (vasopressor) responsiveness to exercise (EEBPR) (n = 5). Lower absolute and varying oxygen consumption/body weight normalized units of middle cerebral arterial blood flow velocity (MCAV) were found during exercise in the experimental group (P <.01). These findings support the hypothesis that the combination of EEBPR and high BMI is associated with low MCAV that may put such individuals at risk for cerebral hypoperfusion and cognitive deficits.

Original languageEnglish (US)
Pages (from-to)370-376
Number of pages7
JournalClinical and Experimental Hypertension
Volume34
Issue number5
DOIs
StatePublished - Aug 2012
Externally publishedYes

Keywords

  • Blood flow velocity
  • Cerebral blood flow
  • Exercise
  • Humans
  • Hypertension
  • Middle cerebral artery

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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