Exact confidence intervals following a group sequential trial: A comparison of methods

Gary L. Rosner; Anastasios A. Tsiatis

doi:10.1093/biomet/75.4.723

Exact confidence intervals following a group sequential trial: A comparison of methods

Gary L. Rosner, Anastasios A. Tsiatis

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

With interest in designing group sequential clinical trials increasing, methodology for analysing the data arising in such trials is needed. We discuss several approaches to constructing confidence intervals for the parameter of interest in a group sequential trial after the trial has ended. We compare these methods to one already in the literature and point out interesting differences.

Original language	English (US)
Pages (from-to)	723-729
Number of pages	7
Journal	Biometrika
Volume	75
Issue number	4
DOIs	https://doi.org/10.1093/biomet/75.4.723
State	Published - Dec 1988
Externally published	Yes

Keywords

Coverage probability
Repeated significance tests
Score function

ASJC Scopus subject areas

Statistics and Probability
Mathematics(all)
Agricultural and Biological Sciences (miscellaneous)
Agricultural and Biological Sciences(all)
Statistics, Probability and Uncertainty
Applied Mathematics

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10.1093/biomet/75.4.723

Cite this

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title = "Exact confidence intervals following a group sequential trial: A comparison of methods",

abstract = "With interest in designing group sequential clinical trials increasing, methodology for analysing the data arising in such trials is needed. We discuss several approaches to constructing confidence intervals for the parameter of interest in a group sequential trial after the trial has ended. We compare these methods to one already in the literature and point out interesting differences.",

keywords = "Coverage probability, Repeated significance tests, Score function",

author = "Rosner, {Gary L.} and Tsiatis, {Anastasios A.}",

note = "Funding Information: This research was supported by the National Cancer Institute. We thank the referees for helpful comments.",

year = "1988",

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doi = "10.1093/biomet/75.4.723",

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T2 - A comparison of methods

AU - Rosner, Gary L.

AU - Tsiatis, Anastasios A.

N1 - Funding Information: This research was supported by the National Cancer Institute. We thank the referees for helpful comments.

PY - 1988/12

Y1 - 1988/12

N2 - With interest in designing group sequential clinical trials increasing, methodology for analysing the data arising in such trials is needed. We discuss several approaches to constructing confidence intervals for the parameter of interest in a group sequential trial after the trial has ended. We compare these methods to one already in the literature and point out interesting differences.

AB - With interest in designing group sequential clinical trials increasing, methodology for analysing the data arising in such trials is needed. We discuss several approaches to constructing confidence intervals for the parameter of interest in a group sequential trial after the trial has ended. We compare these methods to one already in the literature and point out interesting differences.

KW - Coverage probability

KW - Repeated significance tests

KW - Score function

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Exact confidence intervals following a group sequential trial: A comparison of methods

Abstract

Keywords

ASJC Scopus subject areas

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