Exact confidence intervals following a group sequential trial: A comparison of methods

Gary L. Rosner, Anastasios A. Tsiatis

Research output: Contribution to journalArticlepeer-review

Abstract

With interest in designing group sequential clinical trials increasing, methodology for analysing the data arising in such trials is needed. We discuss several approaches to constructing confidence intervals for the parameter of interest in a group sequential trial after the trial has ended. We compare these methods to one already in the literature and point out interesting differences.

Original languageEnglish (US)
Pages (from-to)723-729
Number of pages7
JournalBiometrika
Volume75
Issue number4
DOIs
StatePublished - Dec 1988
Externally publishedYes

Keywords

  • Coverage probability
  • Repeated significance tests
  • Score function

ASJC Scopus subject areas

  • Statistics and Probability
  • Mathematics(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Agricultural and Biological Sciences(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics

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