Exacerbation of Plasmodium yoelii malaria in Echinostoma caproni infected mice and abatement through anthelmintic treatment

Gregory S. Noland, Thaddeus K. Graczyk, Bernard Fried, Erik J. Fitzgerald, Nirbhay Kumar

Research output: Contribution to journalArticle

Abstract

The effect of chronic intestinal trematode infection on malaria was examined in a murine model of co-infection using Echinostoma caproni and Plasmodium yoelii. BALB/c mice (n = 32) infected with a low dose of E. caproni (∼10 cysts) 25-35 days before malaria infection displayed significantly increased malaria parasitemia (P = 0.01), extended patency of malaria (P = 0.03), and increased fatality (47%; P <0.001) compared to mice infected only with P. yoelli (17X nonlethal strain) (n = 18). Further analysis revealed that differences in malaria parasitemia between fatal co-infections and infections with P. yoelii only were highly significant (P <0.0001), whereas nonfatal co-infections were not statistically different. Exacerbation of malaria was demonstrated to be reversible through clearance of E. caproni worms by praziquantel treatment administered 10 days before malaria infection. No deaths were observed during malaria infection in mice cleared of their E. caproni infection (n = 10), and parasitemia was significantly reduced from that of untreated co-infected mice (P = 0.03) and was not different from that of mice infected with P. yoelii only. Further studies examining parasite-parasite interactions and host immune response in the echinostome model are warranted to understand the mechanisms affecting the course and outcome of malaria infection during concomitant helminth infection.

Original languageEnglish (US)
Pages (from-to)944-948
Number of pages5
JournalJournal of Parasitology
Volume91
Issue number4
DOIs
StatePublished - Aug 2005

Fingerprint

Echinostoma
Echinostoma caproni
Plasmodium yoelii
Plasmodium malariae
Anthelmintics
malaria
anthelmintics
Malaria
mice
mixed infection
Infection
Parasitemia
parasitemia
Coinfection
infection
Trematode Infections
parasite
trematode infections
helminthiasis
praziquantel

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Parasitology
  • Microbiology

Cite this

Exacerbation of Plasmodium yoelii malaria in Echinostoma caproni infected mice and abatement through anthelmintic treatment. / Noland, Gregory S.; Graczyk, Thaddeus K.; Fried, Bernard; Fitzgerald, Erik J.; Kumar, Nirbhay.

In: Journal of Parasitology, Vol. 91, No. 4, 08.2005, p. 944-948.

Research output: Contribution to journalArticle

Noland, Gregory S. ; Graczyk, Thaddeus K. ; Fried, Bernard ; Fitzgerald, Erik J. ; Kumar, Nirbhay. / Exacerbation of Plasmodium yoelii malaria in Echinostoma caproni infected mice and abatement through anthelmintic treatment. In: Journal of Parasitology. 2005 ; Vol. 91, No. 4. pp. 944-948.
@article{9f312bd96dec423aa3b9776af2b92505,
title = "Exacerbation of Plasmodium yoelii malaria in Echinostoma caproni infected mice and abatement through anthelmintic treatment",
abstract = "The effect of chronic intestinal trematode infection on malaria was examined in a murine model of co-infection using Echinostoma caproni and Plasmodium yoelii. BALB/c mice (n = 32) infected with a low dose of E. caproni (∼10 cysts) 25-35 days before malaria infection displayed significantly increased malaria parasitemia (P = 0.01), extended patency of malaria (P = 0.03), and increased fatality (47{\%}; P <0.001) compared to mice infected only with P. yoelli (17X nonlethal strain) (n = 18). Further analysis revealed that differences in malaria parasitemia between fatal co-infections and infections with P. yoelii only were highly significant (P <0.0001), whereas nonfatal co-infections were not statistically different. Exacerbation of malaria was demonstrated to be reversible through clearance of E. caproni worms by praziquantel treatment administered 10 days before malaria infection. No deaths were observed during malaria infection in mice cleared of their E. caproni infection (n = 10), and parasitemia was significantly reduced from that of untreated co-infected mice (P = 0.03) and was not different from that of mice infected with P. yoelii only. Further studies examining parasite-parasite interactions and host immune response in the echinostome model are warranted to understand the mechanisms affecting the course and outcome of malaria infection during concomitant helminth infection.",
author = "Noland, {Gregory S.} and Graczyk, {Thaddeus K.} and Bernard Fried and Fitzgerald, {Erik J.} and Nirbhay Kumar",
year = "2005",
month = "8",
doi = "10.1645/GE-456R.1",
language = "English (US)",
volume = "91",
pages = "944--948",
journal = "Journal of Parasitology",
issn = "0022-3395",
publisher = "American Society of Parasitologists",
number = "4",

}

TY - JOUR

T1 - Exacerbation of Plasmodium yoelii malaria in Echinostoma caproni infected mice and abatement through anthelmintic treatment

AU - Noland, Gregory S.

AU - Graczyk, Thaddeus K.

AU - Fried, Bernard

AU - Fitzgerald, Erik J.

AU - Kumar, Nirbhay

PY - 2005/8

Y1 - 2005/8

N2 - The effect of chronic intestinal trematode infection on malaria was examined in a murine model of co-infection using Echinostoma caproni and Plasmodium yoelii. BALB/c mice (n = 32) infected with a low dose of E. caproni (∼10 cysts) 25-35 days before malaria infection displayed significantly increased malaria parasitemia (P = 0.01), extended patency of malaria (P = 0.03), and increased fatality (47%; P <0.001) compared to mice infected only with P. yoelli (17X nonlethal strain) (n = 18). Further analysis revealed that differences in malaria parasitemia between fatal co-infections and infections with P. yoelii only were highly significant (P <0.0001), whereas nonfatal co-infections were not statistically different. Exacerbation of malaria was demonstrated to be reversible through clearance of E. caproni worms by praziquantel treatment administered 10 days before malaria infection. No deaths were observed during malaria infection in mice cleared of their E. caproni infection (n = 10), and parasitemia was significantly reduced from that of untreated co-infected mice (P = 0.03) and was not different from that of mice infected with P. yoelii only. Further studies examining parasite-parasite interactions and host immune response in the echinostome model are warranted to understand the mechanisms affecting the course and outcome of malaria infection during concomitant helminth infection.

AB - The effect of chronic intestinal trematode infection on malaria was examined in a murine model of co-infection using Echinostoma caproni and Plasmodium yoelii. BALB/c mice (n = 32) infected with a low dose of E. caproni (∼10 cysts) 25-35 days before malaria infection displayed significantly increased malaria parasitemia (P = 0.01), extended patency of malaria (P = 0.03), and increased fatality (47%; P <0.001) compared to mice infected only with P. yoelli (17X nonlethal strain) (n = 18). Further analysis revealed that differences in malaria parasitemia between fatal co-infections and infections with P. yoelii only were highly significant (P <0.0001), whereas nonfatal co-infections were not statistically different. Exacerbation of malaria was demonstrated to be reversible through clearance of E. caproni worms by praziquantel treatment administered 10 days before malaria infection. No deaths were observed during malaria infection in mice cleared of their E. caproni infection (n = 10), and parasitemia was significantly reduced from that of untreated co-infected mice (P = 0.03) and was not different from that of mice infected with P. yoelii only. Further studies examining parasite-parasite interactions and host immune response in the echinostome model are warranted to understand the mechanisms affecting the course and outcome of malaria infection during concomitant helminth infection.

UR - http://www.scopus.com/inward/record.url?scp=24944569171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24944569171&partnerID=8YFLogxK

U2 - 10.1645/GE-456R.1

DO - 10.1645/GE-456R.1

M3 - Article

C2 - 17089770

AN - SCOPUS:24944569171

VL - 91

SP - 944

EP - 948

JO - Journal of Parasitology

JF - Journal of Parasitology

SN - 0022-3395

IS - 4

ER -