Ex vivo biomarkers: Functional tools to guide targeted drug development and therapy

Douglas P. Clark

Research output: Contribution to journalReview article

Abstract

Most of the currently utilized predictive biomarkers for therapeutic decision-making provide information regarding the presence or absence of the drug target but reveal little about the functional circuitry of the signaling network that the drug must also impact. Ex vivo biomarkers are dynamic molecular markers evoked from living tumor cells after removal from the patient. Such ex vivo biomarkers provide valuable mechanistic information that may facilitate drug development and guide the clinical selection of targeted therapeutics.

Original languageEnglish (US)
Pages (from-to)787-794
Number of pages8
JournalExpert Review of Molecular Diagnostics
Volume9
Issue number8
DOIs
StatePublished - Nov 1 2009

Keywords

  • Biomarker
  • Drug development
  • Oncology
  • Predictive marker
  • Signal transduction
  • Targeted therapy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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