Abstract
Most of the currently utilized predictive biomarkers for therapeutic decision-making provide information regarding the presence or absence of the drug target but reveal little about the functional circuitry of the signaling network that the drug must also impact. Ex vivo biomarkers are dynamic molecular markers evoked from living tumor cells after removal from the patient. Such ex vivo biomarkers provide valuable mechanistic information that may facilitate drug development and guide the clinical selection of targeted therapeutics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 787-794 |
| Number of pages | 8 |
| Journal | Expert Review of Molecular Diagnostics |
| Volume | 9 |
| Issue number | 8 |
| DOIs | |
| State | Published - Nov 2009 |
| Externally published | Yes |
Keywords
- Biomarker
- Drug development
- Oncology
- Predictive marker
- Signal transduction
- Targeted therapy
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Medicine
- Molecular Biology
- Genetics