Ewing's sarcoma: A case report of a 52-year-old woman with recurrent tumor and literature review

Waseem Khaliq, Mohammad Farshad Bahador, Thomas Nichols Laurence, Ronald Andrew Sapiente, James Sheridan Lewis, David Lee Graham

Research output: Contribution to journalArticle

Abstract

Ewing's sarcoma is the second most common primary sacral tumor. Ewing's sarcomas are rare, aggressive tumors with a tendency towards recurrence following resection and early metastasis. Although peak incidences are between the ages of 10 and 20 years, patients of younger or older age account for almost 30% of the cases. We report the case of a 52-year-old healthy female who presented with a 2-week history of pain in her right posterior thigh that was unable to be relieved by non-steroidal anti-inflammatory medicine and physical therapy. Magnetic resonance imaging demonstrated an irregular right presacral mass and core needle biopsy revealed a small, round blue cell neoplasm. Staging workup was normal and an open biopsy was positive for the ES translocation (22q12). The patient was treated with 17 cycles of vincristine, adriamycin and cytoxan with mesna rescue, alternating with ifosfamide and etoposide in addition to external beam radiation. Post-treatment imaging demonstrated complete resolution of the tumor. Six weeks post-treatment the patient presented with a recurrent tumor. This case emphasizes the importance of timely establishment of initial diagnosis, early metastasis in treatment responsive patients and under-utilization of positron emission tomography-computed tomography (PET-CT) during the treatment to detect sub-clinical metastasis.

Original languageEnglish (US)
Pages (from-to)155-158
Number of pages4
JournalOncology Letters
Volume3
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Ewing's Sarcoma
Neoplasms
Neoplasm Metastasis
Mesna
Large-Core Needle Biopsy
Therapeutics
Physical and Rehabilitation Medicine
Ifosfamide
Vincristine
Etoposide
Thigh
Doxorubicin
Cyclophosphamide
Anti-Inflammatory Agents
Magnetic Resonance Imaging
Radiation
Biopsy
Recurrence
Pain
Incidence

Keywords

  • Ewing's sarcoma
  • Leg pain
  • Microscopic metastases
  • Multimodal therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Khaliq, W., Bahador, M. F., Laurence, T. N., Sapiente, R. A., Lewis, J. S., & Graham, D. L. (2012). Ewing's sarcoma: A case report of a 52-year-old woman with recurrent tumor and literature review. Oncology Letters, 3(1), 155-158. https://doi.org/10.3892/ol.2011.440

Ewing's sarcoma : A case report of a 52-year-old woman with recurrent tumor and literature review. / Khaliq, Waseem; Bahador, Mohammad Farshad; Laurence, Thomas Nichols; Sapiente, Ronald Andrew; Lewis, James Sheridan; Graham, David Lee.

In: Oncology Letters, Vol. 3, No. 1, 01.2012, p. 155-158.

Research output: Contribution to journalArticle

Khaliq, W, Bahador, MF, Laurence, TN, Sapiente, RA, Lewis, JS & Graham, DL 2012, 'Ewing's sarcoma: A case report of a 52-year-old woman with recurrent tumor and literature review', Oncology Letters, vol. 3, no. 1, pp. 155-158. https://doi.org/10.3892/ol.2011.440
Khaliq, Waseem ; Bahador, Mohammad Farshad ; Laurence, Thomas Nichols ; Sapiente, Ronald Andrew ; Lewis, James Sheridan ; Graham, David Lee. / Ewing's sarcoma : A case report of a 52-year-old woman with recurrent tumor and literature review. In: Oncology Letters. 2012 ; Vol. 3, No. 1. pp. 155-158.
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