TY - JOUR
T1 - Evolving Role of Stereotactic Body Radiation Therapy in the Management of Spine Metastases
T2 - Defining Dose and Dose Constraints
AU - Moraes, Fabio Y.
AU - Chen, Xuguang
AU - Yan, Michael
AU - Spratt, Daniel E.
AU - Redmond, Kristen
AU - Jackson, William C.
AU - Yamada, Yoshiya (Josh)
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/4
Y1 - 2020/4
N2 - When treating solid tumor spine metastases, stereotactic high-dose-per-fraction radiation, given in a single fraction or in a hypofractionated approach, has proved to be a highly effective and safe therapeutic option for any tumor histology, in the setting of de novo therapy, as salvage treatment of local progression after previous radiation, and in the postoperative setting. There are variations in practice based on the clinical presentation, goals of therapy, as well as institutional preferences. As a biologically potent therapy, a thoughtful and careful attention to detail with patient selection, treatment planning, and delivery is crucial for treatment success.
AB - When treating solid tumor spine metastases, stereotactic high-dose-per-fraction radiation, given in a single fraction or in a hypofractionated approach, has proved to be a highly effective and safe therapeutic option for any tumor histology, in the setting of de novo therapy, as salvage treatment of local progression after previous radiation, and in the postoperative setting. There are variations in practice based on the clinical presentation, goals of therapy, as well as institutional preferences. As a biologically potent therapy, a thoughtful and careful attention to detail with patient selection, treatment planning, and delivery is crucial for treatment success.
KW - Hypofractionated stereotactic body radiation therapy
KW - Reirradiation of spine metastases
KW - Spine SBRT
KW - Spine radiosurgery dose constraints
KW - Stereotactic spine radiosurgery
KW - Treatment planning
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U2 - 10.1016/j.nec.2019.12.001
DO - 10.1016/j.nec.2019.12.001
M3 - Review article
C2 - 32147009
AN - SCOPUS:85078833755
SN - 1042-3680
VL - 31
SP - 167
EP - 189
JO - Neurosurgery clinics of North America
JF - Neurosurgery clinics of North America
IS - 2
ER -