Evolving adaptive immunity

Geoffrey A. Lovely, Ranjan Sen

Research output: Contribution to journalArticlepeer-review

Abstract

Generation of a diverse repertoire of antigen receptor specificities via DNA recombination underpins adaptive immunity. In this issue of Genes &Development, Carmona and colleagues (pp. 909–917) provide novel insights into the origin and function of recombination-activating gene 1 (RAG1) and RAG2, the lymphocyte-specific components of the recombinase involved in the process.

Original languageEnglish (US)
Pages (from-to)873-875
Number of pages3
JournalGenes & development
Volume30
Issue number8
DOIs
StatePublished - Apr 15 2016
Externally publishedYes

Keywords

  • Evolution
  • RAG
  • Transib
  • Transposition
  • V(D)J recombination

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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