Abstract
Generation of a diverse repertoire of antigen receptor specificities via DNA recombination underpins adaptive immunity. In this issue of Genes &Development, Carmona and colleagues (pp. 909–917) provide novel insights into the origin and function of recombination-activating gene 1 (RAG1) and RAG2, the lymphocyte-specific components of the recombinase involved in the process.
Original language | English (US) |
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Pages (from-to) | 873-875 |
Number of pages | 3 |
Journal | Genes & development |
Volume | 30 |
Issue number | 8 |
DOIs | |
State | Published - Apr 15 2016 |
Externally published | Yes |
Keywords
- Evolution
- RAG
- Transib
- Transposition
- V(D)J recombination
ASJC Scopus subject areas
- Genetics
- Developmental Biology