TY - JOUR
T1 - Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes
AU - Waterhouse, Robert M.
AU - Kriventseva, Evgenia V.
AU - Meister, Stephan
AU - Xi, Zhiyong
AU - Alvarez, Kanwal S.
AU - Bartholomay, Lyric C.
AU - Barillas-Mury, Carolina
AU - Bian, Guowu
AU - Blandin, Stephanie
AU - Christensen, Bruce M.
AU - Dong, Yuemei
AU - Jiang, Haobo
AU - Kanost, Michael R.
AU - Koutsos, Anastasios C.
AU - Levashina, Elena A.
AU - Li, Jianyong
AU - Ligoxygakis, Petros
AU - MacCallum, Robert M.
AU - Mayhew, George F.
AU - Mendes, Antonio
AU - Michel, Kristin
AU - Osta, Mike A.
AU - Paskewitz, Susan
AU - Sang, Woon Shin
AU - Vlachou, Dina
AU - Wang, Lihui
AU - Wei, Qi
AU - Zheng, Liangbiao
AU - Zou, Zhen
AU - Severson, David W.
AU - Raikhel, Alexander S.
AU - Kafatos, Fotis C.
AU - Dimopoulos, George
AU - Zdobnov, Evgeny M.
AU - Christophides, George K.
PY - 2007/6/22
Y1 - 2007/6/22
N2 - Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.
AB - Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.
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U2 - 10.1126/science.1139862
DO - 10.1126/science.1139862
M3 - Article
C2 - 17588928
AN - SCOPUS:34250860637
SN - 0036-8075
VL - 316
SP - 1738
EP - 1743
JO - Science
JF - Science
IS - 5832
ER -