Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: What a long, strange tRIP it's been

Research output: Contribution to journalArticle

Abstract

Sterol regulatory element-binding proteins (SREBPs) are a subfamily of basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factors that are conserved from fungi to humans and are defined by two key features: a signature tyrosine residue in the DNA-binding domain, and a membrane-tethering domain that is a target for regulated proteolysis. Recent studies including genome-wide and model organism approaches indicate SREBPs coordinate cellular lipid metabolism with other cellular physiologic processes. These functions are broadly related as cellular adaptation to environmental changes ranging from nutrient fluctuations to toxin exposure. This review integrates classic features of the SREBP pathway with newer information regarding the regulation and sensing mechanisms that serve to assimilate different cellular physiologic processes for optimal function and growth.

Original languageEnglish (US)
Pages (from-to)2578-2591
Number of pages14
JournalGenes & development
Volume23
Issue number22
DOIs
StatePublished - Nov 15 2009

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Sterol Regulatory Element Binding Proteins
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Lipid Metabolism
Proteolysis
Tyrosine
Fungi
Genome
Food
Membranes
DNA
Growth

Keywords

  • Cell-environment
  • INSIG
  • Nutrient fluctuation
  • SCAP
  • SREBPs

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

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abstract = "Sterol regulatory element-binding proteins (SREBPs) are a subfamily of basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factors that are conserved from fungi to humans and are defined by two key features: a signature tyrosine residue in the DNA-binding domain, and a membrane-tethering domain that is a target for regulated proteolysis. Recent studies including genome-wide and model organism approaches indicate SREBPs coordinate cellular lipid metabolism with other cellular physiologic processes. These functions are broadly related as cellular adaptation to environmental changes ranging from nutrient fluctuations to toxin exposure. This review integrates classic features of the SREBP pathway with newer information regarding the regulation and sensing mechanisms that serve to assimilate different cellular physiologic processes for optimal function and growth.",
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