Evolutionary aspects of human exercise-Born to run purposefully

Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

This article is intended to raise awareness of the adaptive value of endurance exercise (particularly running) in the evolutionary history of humans, and the implications of the genetic disposition to exercise for the aging populations of modern technology-driven societies. The genome of . Homo sapiens has evolved to support the svelte phenotype of an endurance runner, setting him/her apart from all other primates. The cellular and molecular mechanisms underlying the competitive advantages conferred by exercise capacity in youth can also provide a survival benefit beyond the reproductive period. These mechanisms include up-regulation of genes encoding proteins involved in protecting cells against oxidative stress, disposing of damaged proteins and organelles, and enhancing bioenergetics. Particularly fascinating are the signaling mechanisms by which endurance running changes the structure and functional capabilities of the brain and, conversely, the mechanisms by which the brain integrates metabolic, cardiovascular and behavioral responses to exercise. As an emerging example, I highlight the roles of brain-derived neurotrophic factor (BDNF) as a mediator of the effects of exercise on the brain, and BDNF's critical role in regulating metabolic and cardiovascular responses to endurance running. A better understanding of such 'healthspan-extending' actions of endurance exercise may lead to new approaches for improving quality of life as we advance in the coming decades and centuries.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalAgeing Research Reviews
Volume11
Issue number3
DOIs
StatePublished - Jul 2012
Externally publishedYes

Fingerprint

Durability
Exercise
Brain
Running
Brain-Derived Neurotrophic Factor
Gene encoding
Oxidative stress
Medical Genetics
Proteins
Organelles
Energy Metabolism
Primates
Genes
Aging of materials
Reproduction
Oxidative Stress
Up-Regulation
History
Quality of Life
Genome

Keywords

  • Adaptive advantage
  • Competition
  • Endurance
  • Energy intake and expenditure
  • Evolution
  • Learning and memory

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Neurology

Cite this

Evolutionary aspects of human exercise-Born to run purposefully. / Mattson, Mark P.

In: Ageing Research Reviews, Vol. 11, No. 3, 07.2012, p. 347-352.

Research output: Contribution to journalArticle

Mattson, Mark P. / Evolutionary aspects of human exercise-Born to run purposefully. In: Ageing Research Reviews. 2012 ; Vol. 11, No. 3. pp. 347-352.
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