Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis

Ming Tang, Mingjie Wang, Changji Shi, Pablo A Iglesias, Peter N Devreotes, Chuan Hsiang Huang

Research output: Contribution to journalArticle

Abstract

Numerous models explain how cells sense and migrate towards shallow chemoattractant gradients. Studies show that an excitable signal transduction network acts as a pacemaker that controls the cytoskeleton to drive motility. Here we show that this network is required to link stimuli to actin polymerization and chemotactic motility and we distinguish the various models of chemotaxis. First, signalling activity is suppressed towards the low side in a gradient or following removal of uniform chemoattractant. Second, signalling activities display a rapid shut off and a slower adaptation during which responsiveness to subsequent test stimuli decline. Simulations of various models indicate that these properties require coupled adaptive and excitable networks. Adaptation involves a G-protein-independent inhibitor, as stimulation of cells lacking G-protein function suppresses basal activities. The salient features of the coupled networks were observed for different chemoattractants in Dictyostelium and in human neutrophils, suggesting an evolutionarily conserved mechanism for eukaryotic chemotaxis.

Original languageEnglish (US)
Article number5175
JournalNature Communications
Volume5
DOIs
StatePublished - 2014

Fingerprint

Chemotactic Factors
Chemotaxis
GTP-Binding Proteins
locomotion
stimuli
Pacemakers
Signal transduction
Dictyostelium
neutrophils
proteins
Cytoskeleton
Polymerization
gradients
Actins
Signal Transduction
Neutrophils
cells
stimulation
inhibitors
polymerization

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis. / Tang, Ming; Wang, Mingjie; Shi, Changji; Iglesias, Pablo A; Devreotes, Peter N; Huang, Chuan Hsiang.

In: Nature Communications, Vol. 5, 5175, 2014.

Research output: Contribution to journalArticle

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