Evolution of the mammalian G protein α subunit multigene family

Thomas M. Wilkie; Debra J. Gilbert; Anne S. Olsen; Xiao Ning Chen; Thomas T. Amatruda; Julie R. Korenberg; Barbara J. Trask; Pieter de Jong; Randall R. Reed; Melvin I. Simon; Nancy A. Jenkins; Neal G. Copeland

doi:10.1038/ng0592-85

Evolution of the mammalian G protein α subunit multigene family

Thomas M. Wilkie, Debra J. Gilbert, Anne S. Olsen, Xiao Ning Chen, Thomas T. Amatruda, Julie R. Korenberg, Barbara J. Trask, Pieter de Jong, Randall R. Reed, Melvin I. Simon, Nancy A. Jenkins, Neal G. Copeland

School of Medicine

Research output: Contribution to journal › Article › peer-review

201 Scopus citations

Abstract

Heterotrimeric guanine nucleotide binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. The multigene family of G protein α subunits, which interact with receptors and effectors, exhibit a high level of sequence diversity. In mammals, 15 Gα subunit genes can be grouped by sequence and functional similarities into four classes. We have determined the murine chromosomal locations of all 15 Gα subunit genes using an interspecific backcross derived from crosses of C57BI/6J and Mus spretus mice. These data, in combination with mapping studies in humans, have provided insight into the events responsible for generating the genetic diversity found in the mammalian α subunit genes and a framework for elucidating the role of the Gα subunits in disease.

Original language	English (US)
Pages (from-to)	85-91
Number of pages	7
Journal	Nature genetics
Volume	1
Issue number	2
DOIs	https://doi.org/10.1038/ng0592-85
State	Published - May 1992

ASJC Scopus subject areas

Genetics

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title = "Evolution of the mammalian G protein α subunit multigene family",

abstract = "Heterotrimeric guanine nucleotide binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. The multigene family of G protein α subunits, which interact with receptors and effectors, exhibit a high level of sequence diversity. In mammals, 15 Gα subunit genes can be grouped by sequence and functional similarities into four classes. We have determined the murine chromosomal locations of all 15 Gα subunit genes using an interspecific backcross derived from crosses of C57BI/6J and Mus spretus mice. These data, in combination with mapping studies in humans, have provided insight into the events responsible for generating the genetic diversity found in the mammalian α subunit genes and a framework for elucidating the role of the Gα subunits in disease.",

author = "Wilkie, {Thomas M.} and Gilbert, {Debra J.} and Olsen, {Anne S.} and Chen, {Xiao Ning} and Amatruda, {Thomas T.} and Korenberg, {Julie R.} and Trask, {Barbara J.} and {de Jong}, Pieter and Reed, {Randall R.} and Simon, {Melvin I.} and Jenkins, {Nancy A.} and Copeland, {Neal G.}",

year = "1992",

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AU - Wilkie, Thomas M.

AU - Gilbert, Debra J.

AU - Olsen, Anne S.

AU - Chen, Xiao Ning

AU - Amatruda, Thomas T.

AU - Korenberg, Julie R.

AU - Trask, Barbara J.

AU - de Jong, Pieter

AU - Reed, Randall R.

AU - Simon, Melvin I.

AU - Jenkins, Nancy A.

AU - Copeland, Neal G.

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AB - Heterotrimeric guanine nucleotide binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. The multigene family of G protein α subunits, which interact with receptors and effectors, exhibit a high level of sequence diversity. In mammals, 15 Gα subunit genes can be grouped by sequence and functional similarities into four classes. We have determined the murine chromosomal locations of all 15 Gα subunit genes using an interspecific backcross derived from crosses of C57BI/6J and Mus spretus mice. These data, in combination with mapping studies in humans, have provided insight into the events responsible for generating the genetic diversity found in the mammalian α subunit genes and a framework for elucidating the role of the Gα subunits in disease.

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Evolution of the mammalian G protein α subunit multigene family

Abstract

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