TY - JOUR
T1 - Evolution of the β-globin gene cluster in man and the primates
AU - Barrie, P. A.
AU - Jeffreys, A. J.
AU - Scott, A. F.
PY - 1981/7/5
Y1 - 1981/7/5
N2 - The arrangement of primate β-related globin genes has been determined by restriction endonuclease mapping of genomic DNA from species ranging from prosimians to man. The arrangement of the entire ε{lunate}γγδβ-globin gene cluster in the gorilla and the yellow baboon is indistinguishable from that of man. Restriction site differences between these species are consistent with a surprisingly low overall rate of intergenic DNA sequence divergence of approximately 1% in 5 million years. A new world monkey (owl monkey) has a single γ-globin gene, suggesting that the Gγ-Aγ-globin gene duplication in man is ancient, and occurred about 20 to 40 million years ago. The β-globin gene cluster in the brown lemur, a prosimian, is remarkably short (about 20,000 base-pairs) and contains single ε{lunate}-, γ- and β-globin genes. The γ- and β-globin genes in this animal are separated by a curious gene containing the 3′ end of a β-globin gene preceded by sequences related to the 5′ end of the ε{lunate}-globin gene.
AB - The arrangement of primate β-related globin genes has been determined by restriction endonuclease mapping of genomic DNA from species ranging from prosimians to man. The arrangement of the entire ε{lunate}γγδβ-globin gene cluster in the gorilla and the yellow baboon is indistinguishable from that of man. Restriction site differences between these species are consistent with a surprisingly low overall rate of intergenic DNA sequence divergence of approximately 1% in 5 million years. A new world monkey (owl monkey) has a single γ-globin gene, suggesting that the Gγ-Aγ-globin gene duplication in man is ancient, and occurred about 20 to 40 million years ago. The β-globin gene cluster in the brown lemur, a prosimian, is remarkably short (about 20,000 base-pairs) and contains single ε{lunate}-, γ- and β-globin genes. The γ- and β-globin genes in this animal are separated by a curious gene containing the 3′ end of a β-globin gene preceded by sequences related to the 5′ end of the ε{lunate}-globin gene.
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U2 - 10.1016/0022-2836(81)90476-9
DO - 10.1016/0022-2836(81)90476-9
M3 - Article
C2 - 6273584
AN - SCOPUS:0019858060
SN - 0022-2836
VL - 149
SP - 319
EP - 336
JO - Journal of molecular biology
JF - Journal of molecular biology
IS - 3
ER -