Evolution of the β-globin gene cluster in man and the primates

P. A. Barrie, A. J. Jeffreys, Alan F Scott

Research output: Contribution to journalArticle

Abstract

The arrangement of primate β-related globin genes has been determined by restriction endonuclease mapping of genomic DNA from species ranging from prosimians to man. The arrangement of the entire ε{lunate}γγδβ-globin gene cluster in the gorilla and the yellow baboon is indistinguishable from that of man. Restriction site differences between these species are consistent with a surprisingly low overall rate of intergenic DNA sequence divergence of approximately 1% in 5 million years. A new world monkey (owl monkey) has a single γ-globin gene, suggesting that the Gγ-Aγ-globin gene duplication in man is ancient, and occurred about 20 to 40 million years ago. The β-globin gene cluster in the brown lemur, a prosimian, is remarkably short (about 20,000 base-pairs) and contains single ε{lunate}-, γ- and β-globin genes. The γ- and β-globin genes in this animal are separated by a curious gene containing the 3′ end of a β-globin gene preceded by sequences related to the 5′ end of the ε{lunate}-globin gene.

Original languageEnglish (US)
Pages (from-to)319-336
Number of pages18
JournalJournal of Molecular Biology
Volume149
Issue number3
DOIs
StatePublished - Jul 5 1981

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Globins
Multigene Family
Primates
Genes
Strepsirhini
Intergenic DNA
Papio cynocephalus
Lemur
Aotidae
Platyrrhini
Gorilla gorilla
Restriction Mapping
Gene Duplication
Base Pairing
DNA

ASJC Scopus subject areas

  • Virology

Cite this

Evolution of the β-globin gene cluster in man and the primates. / Barrie, P. A.; Jeffreys, A. J.; Scott, Alan F.

In: Journal of Molecular Biology, Vol. 149, No. 3, 05.07.1981, p. 319-336.

Research output: Contribution to journalArticle

Barrie, P. A. ; Jeffreys, A. J. ; Scott, Alan F. / Evolution of the β-globin gene cluster in man and the primates. In: Journal of Molecular Biology. 1981 ; Vol. 149, No. 3. pp. 319-336.
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