Evolution of Neovascularization in Sickle Cell Retinopathy: A Prospective Fluorescein Angiographic Study

Motilal Raichand, Morton F. Goldberg, Krishan C. Nagpal, Michael H. Goldbaum, George K. Asdourian

Research output: Contribution to journalArticlepeer-review

Abstract

With prospective observations we have documented by fluorescein angiography the development of retinal neovascularization in the eyes of patients with sickle cell-hemoglobin C disease (hemoglobin SC). In each patient, arteriolarvenular (AV) anastomoses occurred before the development of neovascular sea fans. To our knowledge, this report constitutes the first such documentation in the literature. New sea fans from AV anastomoses appeared throughout an average interval of 18 months (range, 8 to 36 months) in approximately 21% of young adutls with hemoglobin SC. Each year approximately 14% of young patients with hemoglobin SC may develop retinal neovascularization.

Original languageEnglish (US)
Pages (from-to)1543-1552
Number of pages10
JournalArchives of ophthalmology
Volume95
Issue number9
DOIs
StatePublished - Sep 1977
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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