Evolution of molecular targets for antipsychotic therapy

S. Marenco, Daniel Weinberger

Research output: Contribution to journalReview article

Abstract

The evolution of molecular targets for the treatment of psychosis is briefly summarized. Hypotheses regarding the effectiveness of medications for schizophrenia are also reviewed. While approaches that target dopamine receptors are still the sinequa-non of effective treatment, a considerable evolution has occurred with the introduction of atypical neuroleptics and, lately, of aripiprazole, in terms how how these drugs interact with dopamine receptors. Moreover, new approaches are appearing on the horizon that will target other receptor systems, especially glutamate transmission.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalItalian Journal of Psychopathology
Volume9
Issue number1
StatePublished - Mar 2003
Externally publishedYes

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Molecular Evolution
Dopamine Receptors
Antipsychotic Agents
Psychotic Disorders
Glutamic Acid
Schizophrenia
Therapeutics
Pharmaceutical Preparations
Aripiprazole

Keywords

  • Antipsychotic drugs
  • Dopamine
  • Glutamate
  • Molecular targets
  • Psychosis

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Evolution of molecular targets for antipsychotic therapy. / Marenco, S.; Weinberger, Daniel.

In: Italian Journal of Psychopathology, Vol. 9, No. 1, 03.2003, p. 3-9.

Research output: Contribution to journalReview article

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