Evolution of HIV dementia with HIV infection

Avindra Nath, Nicoline Schiess, Arun Venkatesan, Jeffrey Rumbaugh, Ned Sacktor, Justin Mcarthur

Research output: Contribution to journalReview articlepeer-review


Dementia remains one of the most fearsome complications of HIV infection. It also poses a significant challenge for the clinician both in terms of diagnosis and treatment. The use of antiretroviral agents has led to a decrease in the incidence of HIV dementia but the prevalence of milder forms of neurocognitive impairment has increased. Occasionally, the immune reconstitution caused by these agents may target the brain leading to a syndrome characterized by a severe, progressive and often fatal dementia. The progression of HIV dementia may also be determined by host and viral genetic factors, and the existence of co-morbid factors such as drug abuse, hepatitis C infection and aging. Oxidative stress markers appear to be predictive of active dementia. However, currently there is no specific treatment available for HIV dementia.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalInternational Review of Psychiatry
Issue number1
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Psychiatry and Mental health


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