Evolution of HIV-1 in an HLA-B*57-positive patient during virologic escape

Justin R. Bailey, Haili Zhang, Barbara W. Wegweiser, Hung Chih Yang, Laura Herrera, Aima Ahonkhai, Thomas M. Williams, Robert F. Siliciano, Joel N. Blankson

Research output: Contribution to journalArticlepeer-review

Abstract

Elite suppressors maintain normal CD4+ T cell counts and viral loads of <50 copies of human immunodeficiency virus type 1 (HIV-1) RNA per milliliter of plasma without antiviral therapy. We report here a case of virologic escape in a human leukocyte antigen (HLA)-B*57-positive patient shortly after seroconversion. This escape was associated with the development of mutations in 2 HLA-B*57-restricted CD8+ T cell Gag epitopes, reversion of the drug-resistance mutation M184V, and reversion of a novel polymorphism in Vpu. The present study suggests that control of viral replication in elite suppressors may be due to HIV-1-specific CD8+ T cells and, in some cases, mutations that have subtle effects on viral fitness.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalJournal of Infectious Diseases
Volume196
Issue number1
DOIs
StatePublished - Jul 1 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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