Evolution of HIV-1 in an HLA-B*57-positive patient during virologic escape

Justin Bailey, Haili Zhang, Barbara W. Wegweiser, Hung Chih Yang, Laura Herrera, Aima Ahonkhai, Thomas M. Williams, Robert F Siliciano, Joel N Blankson

Research output: Contribution to journalArticle

Abstract

Elite suppressors maintain normal CD4+ T cell counts and viral loads of + T cell Gag epitopes, reversion of the drug-resistance mutation M184V, and reversion of a novel polymorphism in Vpu. The present study suggests that control of viral replication in elite suppressors may be due to HIV-1-specific CD8+ T cells and, in some cases, mutations that have subtle effects on viral fitness.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalJournal of Infectious Diseases
Volume196
Issue number1
DOIs
Publication statusPublished - Jul 1 2007

    Fingerprint

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this