Evolution of hemoglobin in primates and other therian mammals

John Barnabas, Morris Goodman, G. William Moore

Research output: Contribution to journalArticle

Abstract

1. 1. Phylogenetic trees of twenty-seven alpha and thirty-four betalike mammalian hemoglobin chains and thirty-seven vertebrate globin chains were constructed from amino-acid sequence data. 2. 2. Highlighting the phyletic closeness of African apes to man, the trees provided detailed information on patterns of globin-gene evolution among mammals. 3. 3. Ancestral amino-acid sequences were deduced and mutation distances from branching points in the mammalian beta and alpha trees to descendant sequences calculated. 4. 4. Less alpha and beta change in the descent of higher primates than other mammals was demonstrated and possible selective mechanisms discussed.

Original languageEnglish (US)
Pages (from-to)455-482
Number of pages28
JournalComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Volume39
Issue number3
DOIs
StatePublished - Jul 15 1971
Externally publishedYes

Fingerprint

Mammals
Globins
Primates
Amino Acid Sequence
Hemoglobins
Amino Acids
Hominidae
Vertebrates
Genes
Mutation

Keywords

  • African apes
  • alpha globin chains
  • amino-acid sequences
  • Anthropoidea
  • beta-like globin chains
  • deceleration of molecular evolution
  • dendograms
  • gene duplication
  • gene phylogenetic trees
  • Hemoglobin evolution
  • maternal isoimmunization
  • mutation distances
  • natural selection
  • neutral mutations
  • placentas
  • Primates
  • therian mammals
  • unequal homologous crossing over
  • ungulates
  • unweighted pair group method

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Evolution of hemoglobin in primates and other therian mammals. / Barnabas, John; Goodman, Morris; Moore, G. William.

In: Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, Vol. 39, No. 3, 15.07.1971, p. 455-482.

Research output: Contribution to journalArticle

Barnabas, John ; Goodman, Morris ; Moore, G. William. / Evolution of hemoglobin in primates and other therian mammals. In: Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 1971 ; Vol. 39, No. 3. pp. 455-482.
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